课题基金 / 基金详情

EFFECTS OF MATERNAL PKU ON PREGNANCY OUTCOME

EFFECTS OF MATERNAL PKU ON PREGNANCY OUTCOME
母亲 PKU 对妊娠结局的影响
批准号：
3650838
负责人：
REUBEN MATALON
金额：
$6.5万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-05-16 至 1991-05-15
来源：
https://reporter.nih.gov/project-details/3650838
关键词：
academic achievement child (0-11) child physical development child psychology diet therapy embryo /fetus homozygote human population genetics human pregnant subject human subject mother /embryo /fetus nutrition nutrition disorder chemotherapy nutrition related tag perinatal phenylalanine phenylketonurias

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英文摘要
The level of maternal phenylalanine which will maintain a normal pregnancy. At what stage of pregnancy a low phenylalanine diet is most effective in preventing the effects of maternal PKU on the developing fetus. If the beneficial effects of a low phenylalanine diet can be improved when initiated prior to conception compared to post-conception. Whether the diet reduces the frequency of mental retardation, spontaneous abortions, low birth weight,congenital malformations, neurological and behavioral impairment found in infants of mothers with hyperphenylalaninemia.The levels of tyrosine and trace metals during pregnancy and ascertain the effects of supplementation if levels are found to be low on pregnancy outcome.
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