Regulation of cell reprogramming to pluripotency by complex topographies

通过复杂的拓扑结构调节细胞重编程为多能性

• 批准号: DE150101755
• 负责人: Dr Peng-Yuan Wang
• 金额: $ 24.84万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-06-27 至 2018-06-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE150101755
• 关键词: Regulation; cell; reprogramming; pluripotency; complex

This project aims to use nanotopography approaches to improve the efficiency of generating induced Pluripotent Stem Cells (iPSCs) by changing cell behaviour at biomaterial surfaces. The significance is that iPSCs have enormous potential in stem cell therapy, regenerative medicine, and disease-specific treatment, with the potential to replace other stem cell types. The expected outcomes are that cellular reprogramming process for iPSCs generation will be improved and the canonical reprogramming factors might be reduced using surface nanotopographies of self-assembled colloidal crystals. The benefits are the promotion of productivity, the reduction of costs, and the application of iPSC derivatives, aimed at future clinical applications.

该项目旨在使用纳米形貌方法，通过改变生物材料表面的细胞行为来提高诱导多能干细胞（iPSC）的生成效率。重要的是，iPSC在干细胞治疗，再生医学和疾病特异性治疗方面具有巨大的潜力，并有可能取代其他干细胞类型。预期的结果是，用于iPSCs生成的细胞重编程过程将得到改善，并且使用自组装胶体晶体的表面纳米形貌可以减少典型的重编程因子。其好处是提高生产率，降低成本，并应用iPSC衍生物，旨在未来的临床应用。