VISUAL PERCEPTION AND ALZHEIMER'S DISEASE

视觉感知与阿尔茨海默病

• 批准号: 3809071
• 负责人: GROVER C GILMORE
• 金额: --
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3809071
• 关键词: Alzheimer's disease; brightness discrimination; clinical biomedical equipment; human old age (65+); human subject; image processing; longitudinal human study; memory disorders; neural information processing; neuropsychological tests; perception disorder; psychophysics; visual perception; visual stimulus

Alzheimer's disease is an insidious affliction that cripples the cognitive capabilities of its victims. While memory complaints are the hallmark of the illness, perceptual disorders also are prevalent. Recent research has demonstrated that there are profound deficits in early visual information processing associated with Alzheimer's disease. The evidence suggests that the visual experience of the Alzheimer patient is very different from that of healthy, elderly adults. It is the premise of this proposal that the altered perceptual experiences can have a severe impact on a wide range of perceptual-cognitive functions. The major objective of the research project is to examine the hypothesis that individuals suffering from Alzheimer's disease experience a marked loss in visual perception functions at an early stage of the disease. The objective will be explored through three specific aims using the tools of visual psychophysics and image analysis technology. The first aim is to collect longitudinal, normative data on contrast sensitivity for low and high spatial frequencies from individuals diagnosed with probable Alzheimer's disease, and healthy, elderly adults. It is expected that this measure of visual function will demonstrate a marked loss in Alzheimer's victims that may serve as an early marker of the disease. The second aim is to directly relate the loss of spatial frequency sensitivity to the functional perceptual problems experienced by the patients in basic visual processes such as letter identification, and pattern recognition. Finally, the efficacy of vision and/or stimulus enhancement as an intervention technique for reducing the severity of the perceptual impairment will be explored with the aid of an image engineering workstation that will be developed in the project. The wealth of information made available through this project will assist the clinician in diagnosing dementia. Furthermore, when taken in conjunction with the studies on information processing skills, these data will assist the clinician in describing the true functional capabilities of the patient in the visual processing domain.

阿尔茨海默氏病是一种隐匿的疾病，它会削弱人类的能力 受害者的认知能力。 虽然记忆力抱怨 是疾病的标志，知觉障碍也是 流行。 最近的研究表明，有 早期视觉信息处理的严重缺陷 患有阿尔茨海默病。 有证据表明，视觉 阿尔茨海默病患者的经历与普通人截然不同 健康的老年人。 本提案提出的前提是 感知体验的改变会对人产生严重影响 广泛的知觉认知功能。 该研究项目的主要目标是检查 假设患有阿尔茨海默病的人 早期视觉感知功能明显丧失 疾病的阶段。 该目标将通过三个方面进行探索 使用视觉心理物理学和图像工具的特定目标 分析技术。 第一个目标是收集纵向、 低空间和高空间对比敏感度的规范数据 被诊断患有可能的阿尔茨海默病的个体的频率 疾病和健康的老年人。 预计这 视觉功能的测量将显示出明显的丧失 阿尔茨海默病患者可能是阿尔茨海默病的早期标志 疾病。 第二个目标是直接关联空间损失 对功能知觉问题的频率敏感性 患者在基本视觉过程中所经历的，例如 字母识别、模式识别。 最后， 视觉和/或刺激增强作为干预措施的功效 减轻知觉障碍严重程度的技术 将借助图像工程工作站进行探索 将在该项目中开发。 通过该项目提供的大量信息将 协助临床医生诊断痴呆症。 此外，当 结合信息处理的研究 技能，这些数据将帮助临床医生描述真实的情况 患者视觉处理的功能能力 领域。