EFFECT OF FAT-MODIFIED DIET ON ADOLESCENT HORMONES

脂肪改良饮食对青少年激素的影响

• 批准号: 3676438
• 负责人: SUSAN STERN
• 金额: $ 17.42万
• 依托单位: OGDEN BIOSERVICES CORPORATION
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3676438
• 关键词: cancer registry /resource; tissue resource /registry

The Division of Cancer Prevention and Control, National Cancer Institute (NCI) is conducting a study to evaluate the effect of a fat-modified diet on hormones during childhood and adolescence. The study is being performed ancillary to the Diet Intervention Study in Children (DISC), a randomized clinical trial sponsored by the Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute (NHLBI). The objectives of DISC are to determine whether a fat-modified diet in childhood and adolescence will lower LDL-cholesterol and to assess the feasibility and safety of this diet. The objectives of the NCI ancillary study are to evaluate the effect of this fat-modified diet on sex hormones and to correlate characteristics of children and adolescents, such as age, Tanner stage, anthropometry, diet, and physical activity, with hormone levels. DISC is being conducted at six clinical centers and a coordinating center under a cooperative agreement with NHLBI. A total of 663 children were randomized into the trial beginning in 1986 and it is anticipated that they will be followed through the 2000. The NCI ancillary study on hormones was initiated in 1991. NCI's contract with Ogden BioServices Corporation is to serve as the DISC hormone laboratory. Ogden will store serum collected for the ancillary study, subcontract with a laboratory to assay hormones in serum, develop and implement an external quality control program, and monitor laboratory performance. The contract with Ogden was awarded for the period September 1993 through February 2001. The PI at Ogden is Ms. Susan Greenhut.

国立癌症研究所癌症预防和控制部 (NCI)正在进行一项研究，以评估脂肪改良饮食的效果， 在童年和青春期的荷尔蒙。研究是否 儿童饮食干预研究（DISC）的辅助研究， 一项由流行病学部赞助的随机临床试验， 临床应用，国家心脏，肺和血液研究所（NHLBI）。 DISC的目的是确定是否脂肪改良饮食， 儿童和青少年将降低LDL-胆固醇，并评估 这种饮食的可行性和安全性。NCI辅助的目标 这项研究旨在评估这种脂肪改良饮食对性的影响， 激素和儿童和青少年的相关特征， 例如年龄、坦纳分期、人体测量、饮食和体力活动， 荷尔蒙水平。 DISC正在六个临床中心和一个协调中心进行 根据与NHLBI的合作协议。共有663名儿童 1986年开始随机进入试验，预计 并将在2000年内继续执行。NCI辅助研究 激素是在1991年开始的。 NCI与奥格登生物服务公司的合同是作为DISC 激素实验室奥格登会储存为辅助部队收集的血清 一项研究，与一个实验室一起测定血清中的激素， 制定和实施外部质量控制计划，并监督 实验室性能与奥格登的合同是为了 从1993年9月到2001年2月。奥格登的私家侦探是苏珊女士 格林赫特