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Minimising bone mineral density loss in traumatic amputees: a randomised controlled feasibility trial

最大限度地减少创伤性截肢者的骨矿物质密度损失：一项随机对照可行性试验

基本信息

批准号：
EP/X027155/1
负责人：
Fearghal Behan
金额：
$ 24.26万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FX027155%2F1
关键词：
Minimising bone mineral density loss

项目摘要

Recent conflicts in Iraq and Afghanistan have resulted in a large amount of traumatic or surgical lower limb amputations. Road traffic accidents also produce several extremity injuries (32%), including amputations. Hip bone mineral density (BMD) is reduced following amputation, increasing the risk of hip fractures on the amputated limb. This is compounded by a higher risk of falls in the amputee population. Previous interventions in parallel clinical populations have demonstrated the effectiveness of exercise interventions in recovering BMD loss. However, these types of exercise interventions have not been attempted in the amputee population. BMD loss in amputees appears to be local and mechanical in nature, requiring biomechanically informed interventions. Therefore, immediate investigation on the effectiveness of biomechanically informed interventions to minimise BMD loss in this population is required. To design an intervention where no direct evidence exists, a Delphi process, a consensus method involving experts in the area, would offer a systematic approach that has been applied in the literature extensively. Subsequently, this would inform a randomised controlled feasibility trial to assess the acceptability of an exercise intervention in this population to minimise BMD loss. Consequently, this study aims to design and implement a randomised controlled feasibility study to reduce bone mineral density loss in post-traumatic lower limb amputees.

最近在伊拉克和阿富汗的冲突导致了大量的创伤性或手术性下肢截肢。道路交通事故也会造成一些肢体伤害（32%），包括截肢。髋关节骨矿物质密度（BMD）在截肢后降低，增加了截肢后髋关节骨折的风险。截肢人群中福尔斯跌倒的风险更高，这使情况更加复杂。先前在平行临床人群中的干预已经证明了运动干预在恢复BMD损失方面的有效性。然而，这些类型的运动干预尚未尝试在截肢人群。截肢者的BMD损失似乎是局部的和机械性的，需要生物力学方面的干预。因此，需要立即调查生物力学干预措施的有效性，以最大限度地减少该人群的BMD损失。为了在没有直接证据的情况下设计干预措施，德尔菲过程（一种涉及该领域专家的共识方法）将提供一种已在文献中广泛应用的系统方法。随后，这将为随机对照可行性试验提供信息，以评估该人群中运动干预的可接受性，以最大限度地减少BMD损失。因此，本研究旨在设计和实施一项随机对照可行性研究，以减少创伤后下肢截肢者的骨密度损失。