DNA Repair State Machines

DNA 修复状态机

• 批准号: EP/X027406/1
• 负责人: Mark Dillingham
• 金额: $ 67.6万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX027406%2F1
• 关键词: DNA; Repair; State; Machines

The Doctoral Network RepState aims to train a new generation of innovative scientists in biochemistry and biophysics to address central questions in biology concerning the mode of action of critical DNA Repair proteins that act as state machines. RepState consists of a highly collaborative consortium consisting of 11 participants coming from academia, industry and the creative sector, representing the natural sciences as well as the social sciences. Participating laboratories in RepState are part of established research schools within renowned research organizations and universities. This environment of excellence offers a multidisciplinary PhD program to 10 young researchers, through training in the fundamental chemical and physical principles that underlie biology and human health. In addition, training will focus on method development using technology and experience provided by the academic participants as well as by the two small technology-driven companies. Training incorporates a local program, rotations within partner laboratories, exposure to the non-academic sector and annual meetings. Fellows will follow scientific workshops, courses in transferable skills and career development, and will disseminate and communicate their projects to a diverse audience in close collaboration with the creative sector. The RepState fellows will form a new generation of mature and innovative European scientists with a thorough understanding of fundamental quantitative principles underlying biology, with experience in technique development, career perspectives in multiple sectors and an understanding of the importance of the role of fundamental science for society and human health.

博士网络RepState旨在培养生物化学和生物物理学方面的新一代创新科学家，以解决生物学中有关充当状态机的关键DNA修复蛋白的作用模式的核心问题。RepState由一个高度合作的财团组成，由来自学术界，工业界和创意部门的11名参与者组成，代表自然科学和社会科学。RepState的参与实验室是知名研究机构和大学内已建立的研究学校的一部分。这种卓越的环境提供了一个多学科的博士课程，10名年轻的研究人员，通过培训的基本化学和物理原理，生物学和人类健康的基础。此外，培训将侧重于利用学术参与者以及两个小型技术驱动公司提供的技术和经验制定方法。培训包括当地计划，合作伙伴实验室内的轮换，接触非学术部门和年度会议。研究员将参加科学研讨会，可转移技能和职业发展课程，并与创意部门密切合作，向不同的受众传播和交流他们的项目。RepState研究员将形成新一代成熟和创新的欧洲科学家，他们对生物学的基本定量原理有透彻的了解，在技术开发方面有经验，在多个部门有职业前景，并了解基础科学对社会和人类健康的重要作用。