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STUDIES ON DNA SINGLE STRAND CONFORMATION PREDICTION

STUDIES ON DNA SINGLE STRAND CONFORMATION PREDICTION
DNA单链构象预测研究
批准号：
5200239
负责人：
D NIELSEN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5200239
关键词：
DNA alcoholism /alcohol abuse alleles computer assisted sequence analysis computer program /software disease /disorder proneness /risk genetic polymorphism nucleic acid sequence single strand conformation polymorphism

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中文摘要
翻译
为了确定酗酒易感性的遗传因素，我们
英文摘要
To identify genetic contributions to alcoholism vulnerability, we have been using single-strand conformational polymorphism (SSCP) analysis. SSCP analysis identifies polymorphic alleles through the detection of altered single-strand DNA secondary structure. The altered secondary structure occurs due to nucleotide changes in DNA sequence. To aid in our understanding of the SSCP technique, we have devised a computer program to emulate the folding of single-strand DNAs.
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