IMPULSE PROPAGATION AT ISCHEMIA BOUNDARIES
IMPULSE PROPAGATION AT ISCHEMIA BOUNDARIES
批准号:
3736283
负责人:
WAYNE E CASCIO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
acidity /alkalinity calcium flux carbon dioxide tension catecholamines cell cell interaction cell death cellular polarity confocal scanning microscopy electrophysiology laboratory rabbit myocardial ischemia /hypoxia neural transmission oxygen tension premature ventricular contractions sudden cardiac death ventricular fibrillation video microscopy
中文摘要
本研究的目的是:1)确定高危患者
英文摘要
The aims of this study are: 1) to identify patients at highest risk
of sudden death from ventricular arrhythmia following an acute
myocardial infarction, and 2) to reduce the incidence of this
complication in those patients identified to be at highest risk.
The study population will consist of approximately 425 survivors
of myocardial infarction who have one or more conventional risk
factors for subsequent sudden cardiac death. These patients will
receive electrophysiologic study (EPS) with programmed
ventricular stimulation; Up to 3 ventricular extrastimuli will be
administered in an attempt to induce ventricular tachycardia
(VT). Those patients without inducible VT will be teated with a
beta adrenergic blocking agent only. Of the patients with
inducible VT at EPS, one group will receive beta blockade therapy
only, while another group will receive EPS-guided antiarrhythmic
therapy in additional to beta blockade. These three groups will be
followed long-term to determine whether the results of EPS
predict subsequent sudden cardiac death more accurately than
current techniques, and whether prophylactic therapy guided by
EPS can prevent sudden cardiac death in susceptible patients.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
MECHANISMS AND EFFECT OF CELLULAR CALCIUM ION LOADING IN THE BORDER ZONE
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批准号:6430016
-
项目类别:
-
资助金额:$23.61万
-
财政年份:2001
-
负责人:WAYNE E CASCIO
-
依托单位:
MECHANISMS AND EFFECT OF CELLULAR CALCIUM ION LOADING IN THE BORDER ZONE
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批准号:6564840
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项目类别:
-
资助金额:$23.61万
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财政年份:2001
-
负责人:WAYNE E CASCIO
-
依托单位:
MECHANISMS AND EFFECT OF CELLULAR CALCIUM ION LOADING IN THE BORDER ZONE
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批准号:6302143
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项目类别:
-
资助金额:$23.45万
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财政年份:2000
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负责人:WAYNE E CASCIO
-
依托单位:
MECHANISMS AND EFFECT OF CELLULAR CALCIUM ION LOADING IN THE BORDER ZONE
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批准号:6272631
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项目类别:
-
资助金额:$23.71万
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财政年份:1998
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负责人:WAYNE E CASCIO
-
依托单位:
MECHANISMS AND EFFECT OF CELLULAR CALCIUM ION LOADING IN THE BORDER ZONE
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批准号:6109591
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项目类别:
-
资助金额:$23.45万
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财政年份:1998
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负责人:WAYNE E CASCIO
-
依托单位:
IMPULSE PROPAGATION AT ISCHEMIA BOUNDARIES
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批准号:6241712
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项目类别:
-
资助金额:$21.47万
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财政年份:1997
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负责人:WAYNE E CASCIO
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依托单位:
IMPULSE PROPAGATION AT ISCHEMIA BOUNDARIES
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批准号:5213363
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:WAYNE E CASCIO
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依托单位:--
海外基金