CORE--IMAGING

成像核心有两个主要目标。第一种方法是定义 HIV-1中枢神经系统作用的解剖分布和时程 感染。第二个重要目标是检测和监测 中枢神经系统的机会性感染。在上一个资助期，我们 在影像核心研究了505名受试者。我们已经确定 在临床磁共振检查中可发现的异常发现在 神经学上正常的HIV+受试者，然后主要是 艾滋病。然而，我们的临床研究评级表明，艾滋病毒+受试者 在MRI上比他们的对照组更容易恶化，并且异常 这些发现与疾病进展的其他标记物相关。 我们的磁共振形态计量学研究表明，体积损失发生在灰质 结构，即使在疾病的医学上没有症状的阶段， 尽管抗逆转录病毒药物似乎可以延缓这种损失。的研究 艾滋病患者死后核磁共振检查显示体积减少 在MRI上可测量的与病毒载量分布相关 (Gp41)。成像核心在下一年的主要任务 资助期将在大脑之间建立更强有力的联系 在活体内使用MRI体积技术观察到的结构变化 尸检的发现及其与特定神经认知的关系 改变。为此，仔细关联来自重复磁共振的数据 将进行尸检和尸检。因此，特别 将重点放在所有活体核磁共振检查(和尸检核磁共振 考试)适用于进入神经病理学核心的病例。在 所述目标的服务成像核心将执行 以下功能：1.纵向MRI数据库的收集 (除艾滋病科目外，所有科目一年两次的考试，谁将收到 半年一次的考试)。2.汇编和分析所有国家的研究评级 考试先生。3.所有机会主义者的临床随访和数据库标记 核磁共振检查发现中枢神经系统感染。4.死后核磁共振检查 福尔马林固定病例的左半球(无机会性感染) 进入神经病理核心。5.定量图像分析： 所有活体MRI检查和死后MRI检查的解剖学分析 所有无中枢神经系统机会性感染的神经病理学核心病例 (巨细胞病毒感染病例将包括在内)。磁共振图像的解剖学分析 信息处理项目。地域性技术的开发与应用 功能性磁共振图像数据集的兴趣分析。图像配准和 SPECT研究的感兴趣区分析的发展。

The Imaging Core has two major objectives. The first is to define the anatomical distribution and time course of the CNS effect of HIV-1 infection. A second important objective is to detect and monitor opportunistic infections in the CNS. In the previous funding period we have studied 505 subjects in the Imaging Core. We have established that abnormal findings detectable on clinical MR exams occur infrequently in neurologically-normal HIV+subjects, and then primarily in patients with AIDS. Our clinical research ratings have shown, however, that HIV+subjects more frequently worsen on MRI than do their controls, and the abnormal findings are correlated with other markers for progression of the disease. Our MR morphometry studies suggest that volume loss occurs in gray matter structures, even during the medically asymptomatic stages of the illness, although antiretroviral medication appears to retard this loss. Studies of post-mortem MRI examinations in AIDS patients suggest that volume losses measurable on MRI are correlated with the distribution of viral burden (gp41) in the brain. A major undertaking of the Imaging Core for the next funding period will be to establish stronger links between the brain structural changes observable in vivo using MRI volumetric technique and the findings at autopsy and to relate these to specific neurocognitive changes. To this end, careful correlation of data from repeated MR examinations with post-mortem findings will be performed. Thus, particular emphasis will be placed in all in vivo MRI exams (and the post-mortem MRI exams) available for cases entering the Neuropathology Core. In the service of the stated objectives the Imaging Core will perform the following functions: 1. Collection of a longitudinal MRI database (biannual exams for all subjects except AIDS subjects, who will receive semiannual exams). 2. Compilation and analysis of research ratings of all MR exams. 3. Clinical follow-up and database tagging of all opportunistic CNS infections detected on MRI. 4. Post-mortem MRI examination of the formalin-fixed left hemispheres of cases (without opportunistic infections) entering the Neuropathology Core. 5. Quantitative Image Analysis: Anatomical analysis of all in vivo MRI exams and a post-mortem MRI exam for all Neuropathology Core cases without opportunistic infections of the CNS (cases with CMV will be included). Anatomical analysis of images for MR Information Processing Project. Development and application of region-of- interest analysis for functional MR image datasets. Image registration and development of region-of-interest analysis for SPECT studies.