CORE--IMAGING

成像核心有两个主要目标。 第一个是定义 HIV-1中枢神经系统效应的解剖学分布和时间进程 感染 第二个重要目标是检测和监测 CNS中的机会性感染。 在上一个资助期， 已经研究了成像核心中的505个对象。 我们确定 临床MR检查中可检测到的异常发现很少发生在 神经学正常的HIV+受试者，然后主要是 艾滋病 然而，我们的临床研究评级表明，HIV+受试者 在MRI上比对照组更频繁地恶化，并且异常 这些发现与疾病进展的其他标志物相关。 我们的磁共振形态测量学研究表明，体积损失发生在灰质 结构，即使在疾病的医学无症状阶段， 尽管抗逆转录病毒药物似乎可以延缓这种损失。 研究 艾滋病患者死后的MRI检查表明， 与病毒负荷分布相关 （GP41）在大脑中。 成像核心的一项重大任务， 资金期间将建立更强的联系， 使用MRI体积技术在体内可观察到的结构变化， 尸检的发现，并将这些与特定的神经认知 变化 为此，仔细关联来自重复MR的数据 并会进行验尸。 因此，特别 重点将放在所有体内MRI检查（和尸检MRI）中 考试）可用于进入神经病理学核心的病例。 在 服务的规定目标，成像核心将执行 以下功能：1. 纵向MRI数据库的收集 （所有科目一年两次考试，艾滋病科目除外， 半年考试）。 2. 汇编和分析所有国家的研究评级 MR检查 3. 临床随访和数据库标记所有机会性 MRI上检测到CNS感染。 4. 尸检MRI检查 福尔马林固定的左半球病例（无机会性感染） 进入神经病理学核心。 5. 定量图像分析： 所有体内MRI检查和尸检MRI检查的解剖分析， 所有无CNS机会性感染的神经病理学核心病例 （将纳入CMV病例）。 MR图像的解剖分析 信息处理项目。 开发和应用区域- 功能MR图像数据集兴趣分析。 图像配准和 开发SPECT研究的感兴趣区域分析。

The Imaging Core has two major objectives. The first is to define the anatomical distribution and time course of the CNS effect of HIV-1 infection. A second important objective is to detect and monitor opportunistic infections in the CNS. In the previous funding period we have studied 505 subjects in the Imaging Core. We have established that abnormal findings detectable on clinical MR exams occur infrequently in neurologically-normal HIV+subjects, and then primarily in patients with AIDS. Our clinical research ratings have shown, however, that HIV+subjects more frequently worsen on MRI than do their controls, and the abnormal findings are correlated with other markers for progression of the disease. Our MR morphometry studies suggest that volume loss occurs in gray matter structures, even during the medically asymptomatic stages of the illness, although antiretroviral medication appears to retard this loss. Studies of post-mortem MRI examinations in AIDS patients suggest that volume losses measurable on MRI are correlated with the distribution of viral burden (gp41) in the brain. A major undertaking of the Imaging Core for the next funding period will be to establish stronger links between the brain structural changes observable in vivo using MRI volumetric technique and the findings at autopsy and to relate these to specific neurocognitive changes. To this end, careful correlation of data from repeated MR examinations with post-mortem findings will be performed. Thus, particular emphasis will be placed in all in vivo MRI exams (and the post-mortem MRI exams) available for cases entering the Neuropathology Core. In the service of the stated objectives the Imaging Core will perform the following functions: 1. Collection of a longitudinal MRI database (biannual exams for all subjects except AIDS subjects, who will receive semiannual exams). 2. Compilation and analysis of research ratings of all MR exams. 3. Clinical follow-up and database tagging of all opportunistic CNS infections detected on MRI. 4. Post-mortem MRI examination of the formalin-fixed left hemispheres of cases (without opportunistic infections) entering the Neuropathology Core. 5. Quantitative Image Analysis: Anatomical analysis of all in vivo MRI exams and a post-mortem MRI exam for all Neuropathology Core cases without opportunistic infections of the CNS (cases with CMV will be included). Anatomical analysis of images for MR Information Processing Project. Development and application of region-of- interest analysis for functional MR image datasets. Image registration and development of region-of-interest analysis for SPECT studies.