Control of T helper cells in autoimmunity and anti-tumour responses.

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The proposed studies aim to improve our understanding of the factors that regulate a specialised immune cell type called “T helper” cells and their function in models of autoimmune disease and during anti-tumour immune responses. The project will investigate (1) the role of a signalling protein called Interleukin 27 in these processes and (2) how several novel genes, recently found to be associated with the development of MS in humans, influence T helper cell activity.