CORRELATION OF PLASMA LEVELS IN VWF WITH THE VWF ALLELE AND ABO BLOOD TYPE

VWF 血浆水平与 VWF 等位基因和 ABO 血型的相关性

• 批准号: 3740526
• 负责人: ROBERT MONTGOMERY
• 金额: --
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3740526
• 关键词: ABO(H) blood groups; DNA; alleles; blood chemistry; family genetics; gene expression; genetic disorder; human subject; phenotype; polymerase chain reaction; von Willebrand factor; von Willebrand's disease

This study will tract the inheritance of the vWF alleles in families with known von Willebrand disease or reduced levels of plasma vWF by analysis of DNA through combined use of PCR technology and detection of VNTR. Identification and tracking to these alleles within families can determine if inheritance of the allele corresponds with phenotypic expression of disease.

本研究将追踪vWF等位基因在家族中的遗传， 通过分析已知的血管性血友病或血浆vWF水平降低 PCR技术与VNTR检测相结合， 对这些等位基因在家系中的识别和追踪， 确定等位基因的遗传是否与表型 疾病的表达。