UPREGULATED STATES OF THE 1,25 VITAMIN D RECEPTOR

有证据表明，肾结石患者的吸收 高钙尿症（AH）（经常有脊柱骨质减少）和特发性 骨质疏松症患者（有时有AH）可能代表“上调” 1，25维生素D受体。待检验的假设为： 骨化三醇合成增强导致1，25维生素D上调 导致持续上调状态的受体。 AH将随之而来，如果 肠道是主要受累部位，而特发性 如果骨是关键目标，则会发生骨质疏松症。

There is evidence that kidney stone patients with absorptive hypercalciuria(AH) (who often have spinal osteopenia) and idiopathic osteoporosis patients (who sometimes have AH) may represent "upregulated" states of the 1,25 Vitamin D receptor. The hypothesis to be tested is: enhanced calcitriol synthesis leads to upregulation of 1,25 Vitamin D receptor which leads to sustained upregulated state. AH would ensue if the gut were the primary site of involvement, whereas idiopathic osteoporosis would develop if bone were the key target.