GROWTH HORMONE RX OF HEIGHT DEFICIT IN CHILDREN WITH CHRONIC RENAL INSUFFICIENCY

慢性肾功能不全儿童身高缺陷的生长激素 RX

• 批准号: 3742802
• 负责人: STEVEN R ALEXANDER
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742802
• 关键词: body height; child (0-11); child physical development; chronic renal failure; drug adverse effect; endocrine disorder chemotherapy; hormone therapy; human subject; human therapy evaluation; kidney function; pediatric pharmacology; postnatal growth disorder; recombinant proteins; somatotropin

Children with CRI are often growth retarded and do not achieve normal growth rates with optimal medical management, dialysis treatment or following successful kidney transplantation even when steroid therapy is minimal. The purpose of this study is to determine whether recombinant human growth hormone treatment will result in improved growth in children with moderate renal insufficiency and to determine if there is any untoward effect of rhGH of kidney function.

患有 CRI 的儿童通常生长迟缓并且无法达到正常水平 通过最佳医疗管理、透析治疗或 肾移植成功后，即使类固醇治疗已成功 最小。本研究的目的是确定是否重组 人类生长激素治疗将改善儿童的生长 患有中度肾功能不全并确定是否存在任何 rhGH 对肾功能的不良影响。