GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 2283202
• 负责人: Ward E Bullock
• 金额: $ 114.71万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-15 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2283202
• 关键词: clinical trials; human subject

This application is for a new General Clinical Research Center (GCRC) to be established at the University of Connecticut Health Center (UCHC). This GCRC will be developed as a central outpatient facility since the majority of research proposals involve outpatient studies. For inpatient studies we will use either per diem beds on a designated medical/surgical unit or on a unit such as the Bone Marrow Transplant Unit, the Adult Intensive Care Unit, and the Neonatal Intensive Care Unit. The application contains 23 individual research proposals, the majority of which involve interactions between basic scientists and clinical investigators. There is a special emphasis on the application of new methods of molecular biology and human genetics to the study of the pathogenesis of disease. The protocols cover a wide range of clinical disorders including bone and connective tissue metabolism, hematology and oncology, neurosciences and psychiatry, cardiopulmonary disease and immunologic disorders. In addition to providing facilities and support for these projects, the GCRC will serve as a center for training young investigators in clinical research. Specific training will be provided in the application of new basic science techniques to clinical problems and in the general principles of clinical research, biostatistical analysis and experimental design. The University and the State of Connecticut have made a substantial, ongoing commitment to support the GCRC. State and intramural funds have been provided to support the staff and fund pilot projects to develop this proposal. The UCHC central administration and the Deans of the Schools of Medicine and Dental Medicine have targeted the further development of clinical research as a major goal for the 90's and have demonstrated this through their continued support. Thus, we believe that this GCRC will provide an innovative and effective means of fostering clinical research. The specific research questions we propose to explore as well as the emphasis on interactions between basic and clinical scientists, on outpatient-based protocols and on the training of new investigators should lead to substantial advances in biomedical science for our region and for the nation.

该申请适用于新的普通临床研究中心 (GCRC) 建立在康涅狄格大学健康中心 (UCHC)。这 GCRC 将发展为中心门诊设施，因为大多数 的研究提案涉及门诊研究。 用于住院研究 我们将使用指定医疗/手术单位的每日床位，或者 在骨髓移植科、成人重症监护室等单位 监护病房和新生儿重症监护病房。该应用程序包含 23 项个人研究计划，其中大部分涉及 基础科学家和临床研究人员之间的互动。有 特别强调分子生物学新方法的应用 和人类遗传学来研究疾病的发病机制。这 协议涵盖广泛的临床疾病，包括骨和 结缔组织代谢、血液学和肿瘤学、神经科学和 精神病学、心肺疾病和免疫系统疾病。此外 为了为这些项目提供设施和支持，GCRC 将 作为临床研究年轻研究者的培训中心。 将提供新基础科学应用方面的专门培训 解决临床问题的技术和临床一般原则 研究、生物统计分析和实验设计。 大学和康涅狄格州取得了实质性的进展， 持续致力于支持 GCRC。国家和校内资金 已提供支持工作人员并资助试点项目来开发这一项目 提议。 UCHC 中央行政部门和各学院院长 医学和牙科医学的目标是进一步发展 临床研究作为 90 年代的主要目标，并已证明了这一点 通过他们的持续支持。因此，我们相信本次 GCRC 将 为促进临床研究提供创新且有效的手段。 我们建议探索的具体研究问题以及 强调基础科学家和临床科学家之间的互动 基于门诊的方案和新研究者的培训应 为我们地区和世界带来生物医学科学的重大进步 国家。