GENERAL CLINICAL RESEARCH CENTER

本申请是为了建立一个新的综合临床研究中心（GCRC）， 康涅狄格大学健康中心（UCHC）。这 GCRC将被开发为中心门诊设施，因为大多数 的研究建议涉及门诊研究。 对于住院研究 我们将在指定的医疗/外科单位使用每日床位， 在一个单位，如骨髓移植单位，成人密集 监护室和新生儿重症监护室。应用程序包含 23项研究提案，其中大部分涉及 基础科学家和临床研究者之间的互动。有 特别强调分子生物学新方法的应用 和人类遗传学对疾病发病机理的研究。的 协议涵盖广泛的临床病症，包括骨骼和 结缔组织代谢、血液学和肿瘤学、神经科学和 精神病学、心肺疾病和免疫疾病。此外 为这些项目提供设施和支援， 作为临床研究中年轻研究者的培训中心。 将提供应用新的基础科学的具体培训 技术，以临床问题和临床的一般原则， 研究、生物统计分析和实验设计。 大学和康涅狄格州已经做出了实质性的， 持续承诺支持GCRC。州和校内基金 提供了支持工作人员和基金试点项目，以制定这一 提议UCHC中央行政部门和各学校院长 医学和牙科医学的目标是进一步发展 临床研究作为90年代的主要目标，并已证明这一点 通过他们的持续支持。因此，我们认为，这一GCRC将 提供创新和有效的手段，促进临床研究。 我们建议探索的具体研究问题以及 强调基础和临床科学家之间的互动， 基于门诊的方案和对新研究者的培训应 导致我们区域和森林生物医学科学取得重大进展， 归国

This application is for a new General Clinical Research Center (GCRC) to be established at the University of Connecticut Health Center (UCHC). This GCRC will be developed as a central outpatient facility since the majority of research proposals involve outpatient studies. For inpatient studies we will use either per diem beds on a designated medical/surgical unit or on a unit such as the Bone Marrow Transplant Unit, the Adult Intensive Care Unit, and the Neonatal Intensive Care Unit. The application contains 23 individual research proposals, the majority of which involve interactions between basic scientists and clinical investigators. There is a special emphasis on the application of new methods of molecular biology and human genetics to the study of the pathogenesis of disease. The protocols cover a wide range of clinical disorders including bone and connective tissue metabolism, hematology and oncology, neurosciences and psychiatry, cardiopulmonary disease and immunologic disorders. In addition to providing facilities and support for these projects, the GCRC will serve as a center for training young investigators in clinical research. Specific training will be provided in the application of new basic science techniques to clinical problems and in the general principles of clinical research, biostatistical analysis and experimental design. The University and the State of Connecticut have made a substantial, ongoing commitment to support the GCRC. State and intramural funds have been provided to support the staff and fund pilot projects to develop this proposal. The UCHC central administration and the Deans of the Schools of Medicine and Dental Medicine have targeted the further development of clinical research as a major goal for the 90's and have demonstrated this through their continued support. Thus, we believe that this GCRC will provide an innovative and effective means of fostering clinical research. The specific research questions we propose to explore as well as the emphasis on interactions between basic and clinical scientists, on outpatient-based protocols and on the training of new investigators should lead to substantial advances in biomedical science for our region and for the nation.