GENERAL CLINICAL RESEARCH CENTER

目前的提案是一项为期五年的竞争性续签申请，由 马萨诸塞州综合医院支持其Mallinckrodt综合医院 临床研究中心。GCRC已经满足了临床的需要 调查人员在马萨诸塞州总医院工作了65年以上 好几年了。它得到了美国国立卫生研究院的资助 三十年，最初是作为代谢研究中心(NIAMD)，自1978年以来 作为一个综合临床研究中心(NCRR)。当前应用程序 需要将近2000个病人床日(每个日间研究单位)和1300个 门诊就诊。将利用这些资源的52个协议 代表分布在13个单位的65名研究人员的临床研究 MGH的10个部门。就目前提交的材料而言，主要努力 已经做出了努力，以扩大各部门的调查人员数量 在Mallinckrodt GCRC历史上最活跃的用户之外。 因此，除了内分泌学和新陈代谢方面的方案外，新的 临床研究计划已由以下部门启动 整形外科、儿科外科、精神病学和传染病 医学系疾病和肿瘤科。 Mallinckrodt GCRC为广泛的临床 研究活动，特别是需要频繁、有时间的研究 血液和其他体液的收集，创新和复杂 诊断、治疗和生理技术，仔细控制 饮食、有节制的睡眠时间表或光环境。许多新的 方案包括通常比研究对象病情更重的患者 在过去。除了最近翻新的设施外，GCRC 提供专家护理、复杂的饮食支持、生物统计学 支助、一个新的计算机系统(RS-1)、一个核心实验室为 临床研究人员的需求和其他行政支持 有必要进行临床研究。 GCRC非常积极地培训医生、护士、营养师和 临床调查中的学生。关于GCRC的教育工作 包括通过若干机制(履约协助方案)支持研究生培训 奖项和私人资助的Mallinckrodt临床研究奖学金)， 以导师为基础的培训，为医学生提供的计划和教学 教学计划。 Mallinckrodt GCRC在临床上有着悠久的卓越历史 研究，并一直是临床有意义的进展的地点 医学已有60多年的历史。它将继续充当 MGH的住院临床调查的主要地点。

The current proposal is a five year competitive renewal application by the Massachusetts General Hospital to support its Mallinckrodt General Clinical Research Center. The GCRC has served the needs of clinical investigators at the Massachusetts General Hospital for more than 65 years. It has been funded by the National Institutes of Health for thirty years, first as a metabolic research center (NIAMD) and since 1978 as a General Clinical Research Center (NCRR). The current application requests almost 2000 patient bed days (per diem research unit) and 1300 outpatient visits. The 52 protocols that will utilize these resources represent clinical research from 65 investigators located in 13 units and 10 departments at the MGH. For the current submission, a major effort has been made to expand the number of investigators from departments outside of the historically most active users of the Mallinckrodt GCRC. Therefore, in addition to protocols in endocrinology and metabolism, new clinical research programs have been initiated by the Departments of Orthopedics, Pediatric Surgery, and Psychiatry and by the Infectious Diseases and Oncology Units of the Department of Medicine. The Mallinckrodt GCRC provides facilities for a broad array of clinical research activities, particularly research requiring frequent, timed collections of blood and other body fluids, innovative and complex diagnostic, therapeutic and physiological techniques, careful control of diets, controlled sleep schedules or light environment. Many of the new protocols include patients who are generally more ill than those studied in the past. In addition to its recently renovated facilities, the GCRC offers expert nursing care, sophisticated dietary support, biostatistical support, a new computer system (RS-1), a Core Laboratory to serve the needs of the clinical investigators, and other administrative support necessary to perform clinical investigation. The GCRC is very active in training physicians, nurses, dietitians, and students in clinical investigation. The educational efforts on the GCRC include post-graduate training supported through several mechanisms (CAP awards and a privately funded Mallinckrodt Clinical Research Fellowship), mentor based training, a program for medical students, and a didactic teaching program. The Mallinckrodt GCRC has a long history of excellence in clinical investigation and has been the site of meaningful advances in clinical medicine for more than six decades. It will continue to serve as the major site for inpatient clinical investigation at the MGH.