EFFECT OF ATRIAL NATRIURETIC HORMONE ON VASOPRESSIN REGULATION

心房利尿钠激素对加压素调节的影响

• 批准号: 3744600
• 负责人: YORAM SHENKER
• 金额: --
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3744600
• 关键词: adult human (21+); atrial natriuretic peptide; blood chemistry; blood osmolarity; female; hormone regulation /control mechanism; human subject; menstrual cycle; saline; sodium; thirst; vasopressins

To evaluate AVP and ANH response to hypertonic saline (HS) in relation to different stages of the menstrual cycle, nine healthy young women (age 19-25) were studied twice: once during follicular and once during luteal phase. On both occasions subjects were infused with HS, blood samples were obtained and thirst was assessed. Both AVP and thirst levels were highly correlated to osmolality or serum sodium. We conclude that ANH levels are significantly lower both at baseline and after HS during luteal phase.

探讨AVP和ANH对高渗盐水（HS）的反应， 月经周期的不同阶段，9名健康的年轻女性（年龄 19-25）研究两次：一次在卵泡期，一次在黄体期 相位 在这两种情况下，受试者均输注了HS血液样本 获得并评估口渴。 AVP和口渴水平均为 与渗透压或血清钠高度相关。 我们得出结论，ANH 水平在基线和HS后均显著降低， 黄体期