Correlating Multiple Sclerosis Risk SNPs with immune cell gene expression

将多发性硬化症风险 SNP 与免疫细胞基因表达相关联

• 批准号: nhmrc : 1032486
• 负责人: Dr Jac Charlesworth
• 金额: $ 52.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/correlating-multiple-sclerosis-gene-expression/110852
• 关键词: Correlating; Multiple; Sclerosis; Risk; SNPs

In Multiple Sclerosis (MS), the immune system repeatedly attacks the brain and spinal cord. In the last three years, rapid progress has been made in understanding genetic risk factors for MS, and more than 20 are known, but their function is not understood. The proposed study will recruit patients with MS and healthy controls to isolate five major immune cell types, and will assess how risk genes influence these cells. We hope to obtain a much better picture of how genetic risk factors for MS actually work.

在多发性硬化症（MS）中，免疫系统反复攻击大脑和脊髓。在过去的三年里，在了解MS的遗传风险因素方面取得了快速进展，已知有20多种，但其功能尚不清楚。这项研究将招募MS患者和健康对照，以分离五种主要的免疫细胞类型，并评估风险基因如何影响这些细胞。我们希望更好地了解MS的遗传风险因素是如何起作用的。