课题基金 / 基金详情

MECHANISMS FOR HIV-1 ENHANCEMENT OF EICOSANOID FORMATION

MECHANISMS FOR HIV-1 ENHANCEMENT OF EICOSANOID FORMATION
HIV-1 增强类二十烷酸形成的机制
批准号：
3755461
负责人：
T ELING
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3755461
关键词：
AIDS HIV envelope protein gp120 eicosanoids fatty acid biosynthesis human immunodeficiency virus 1 virus envelope virus protein

项目摘要

项目成果

T ELING的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The object of this project is to determine the mechanism by which the coat proteins (GP-120 and GP-160) from the AID virus enhances the formation of eicosanoids. Our initial effort was devoted to examining several cellular systems, human monocytes, Jurkat T cells and the monocyte line, THP-1 for their ability of metabolizing arachidonic acid to prostaglandins. Preliminary results indicate that the Jurkat cells form only minor amounts of prostaglandins and may not be a suitable model. We are in the process of testing a number of different preparations of GP-120 and GP-160 from several HIV strain for their ability to stimulate PGE2 from human monocytes. We are in the very early phase of this investigation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ROLE OF LIPIDS IN BREAST CANCER
ROLE OF LIPIDS IN COLON CANCER
LINOLEIC ACID METABOLITES WITH PROTEIN TYROSINE KINASES & PHOSPATASES
MECHANISMS THAT REGULATE THE ENZYMES THAT METABOLIZE CIS UNSATURATED FATTY ACIDS