SCOR--LUNG BIOLOGY AND DISEASES IN INFANTS AND CHILDREN

SCOR--婴儿和儿童的肺生物学和疾病

• 批准号: 2214808
• 负责人: ROBERT B COTTON
• 金额: $ 101.51万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-30 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2214808
• 关键词: bronchopulmonary dysplasia; infant human (0-1 year); lung; newborn human (0-6 weeks); respiratory distress syndrome of newborn

Bronchopulmonary dysplasia (BPD) has become the greatest contributor to morbidity in newborn intensive care units. BPD is the clinical consequence of lung injury in the human newborn infant that occurs when functional integrity of the lung is not restored in a timely and orderly manner by the repair process. With a focus on BPD in mind, the goals of this SCOR relate to lung development at the level of cell growth and differentiation, to mechanisms of defense against lung injury, and to repair processes that are initiated in response to lung injury. This SCOR also addresses mechanisms by which clinical interventions can be employed to modify either lung injury or the repair process as a strategy to reduce the incidence and severity of BPD. Finally, in anticipation that the rapidly growing success of lung transplantation will inevitably be extended to the infant with end- stage BPD, this SCOR will attempt to answer questions related to the surfactant system in the transplanted lung, both in regard to performance of the surfactant system in the denervated lung and in regard to the role of surfactant treatment during episodes of rejection. Specific projects in this proposed SCOR involve studies of 1) epidermal growth factor signal transduction in the developing lung, 2) the role of extracellular matrix biosynthesis in fetal rat lung epithelial cell growth and differentiation, 3) the role of pulmonary surfactant associated proteins and related C-type lectins in the lung development, injury and repair, 4) the effects of vitamin A on the regulation of lung epithelial differentiation, 5) the regulation of P450 gene expression and its role in oxidant production by the hyperoxic lung, and 6) the physiologic effects of surfactant treatment in human premature infants. Resources to support these projects are provided by five cores: the Newborn clinical Research Core, the Animal Laboratory Core, the Biomedical Engineering and Informatics Core, the Histopathology and Molecular Biology Core, and the Administrative Core.

支气管肺发育不良（BPD）已成为最大的贡献者， 新生儿重症监护病房的发病率。 BPD是临床结果 肺损伤的人类新生儿发生时，功能 肺的完整性不能及时有序地恢复， 修复过程。 考虑到BPD的重点，本SCOR的目标涉及 在细胞生长和分化水平上的肺发育， 防御肺损伤的机制，并修复被 是由肺损伤引起的 该战略行动报告还涉及机制问题， 通过该方法，可以采用临床干预来改变 损伤或修复过程作为减少发病率的策略， BPD的严重性。 最后，在预期的快速增长的成功， 肺移植将不可避免地扩展到婴儿， BPD阶段，该SCOR将尝试回答与 表面活性剂系统在移植肺中的作用， 表面活性剂系统在失神经肺中的作用， 表面活性剂的治疗。 具体项目 该建议的SCOR涉及1）表皮生长因子信号的研究 2）细胞外基质的作用 生物合成在胎鼠肺上皮细胞生长和分化中的作用， 3)肺表面活性物质相关蛋白及相关C型 凝集素在肺发育、损伤和修复中的作用; 4） 维生素A对肺上皮分化的调节，5） P450基因表达的调控及其在氧化剂产生中的作用 高氧肺，以及6）表面活性剂治疗的生理作用 在人类早产儿中。 支持这些项目的资源包括 由五个核心提供：新生儿临床研究核心，动物 实验室核心，生物医学工程和信息学核心， 组织学和分子生物学核心，以及行政核心。