PURCHASE HEWLETT PACKARD ULTRASONOGRAPHY UNIT

购买惠普超声波检查装置

• 批准号: 2283888
• 负责人: PIA S POLLACK
• 金额: $ 19.8万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 1995-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2283888
• 关键词: biomedical equipment purchase; computer graphics /printing; computer program /software; ultrasound blood flow measurement

The BRS Shared instrumentation grant Proposal will enable Temple University Health Sciences Center to purchase a Hewlett Packard Sonos1500, which is a state-of-the-art computed real time sonography unit with Doppler capability. At least 10 active investigators, 3 of whom are NIH funded, are critically dependent on the availability of such equipment. They have been denied access to comparable equipment because hospital regulations prohibit animal research in patient care facilities. The proposed unit will be housed in research facilities and dedicated to animal experimentation. The users all require high resolution imaging and blood flow measurements in their research. The instrument will play a key role in projects involving 1) molecular mechanisms regulating the development of cardiac hypertrophy, 2) the role of calcium homeostasis in hypertrophied and falling cardiac myocytes, 3) investigation of mechanisms to improve brainstem function and cerebral blood flow in very premature neonatal animals, 4) the efficacy of hypertonic crystalloid resuscitation after spinal cord trauma, 5) pharmaceutical manipulation to prevent damage from cerebral ischemia and reperfusion, 6) portal vein anastamoses following liver transplantation, 7) blood flow in the superior mesenteric artery during neonatal necrotizing vasculitis, 8) investigation of basic mechanisms that contribute to sodium retention and vasoconstriction in congestive heart failure. The Hewlett-Packard Sonos 1500 will make non invasive imaging and blood flow measurements available to these investigators; it will improve the resolution and accuracy of currently available techniques. For example, Doppler techniques will replace radioactive microsphere blood flow methods. The Organizational Plan will be supervised by the internal Advisory Committee which is chaired by Dr. Barbara Wolfson, Chief of the Section of Ultrasound and Professor of Diagnostic Imaging; it includes representatives of the University's Sponsored Projects Administration, the PI and other Temple Faculty. The long term use of this instrument is guaranteed by the oversight of the Internal Advisory Committee and by the commitments of the Chairs of the Departments of Diagnostic imaging and Medicine to cover maintenance costs. Finally, this instrument will be kept in a current animal research facility; no renovations are required.

BRS共享仪器赠款提案将使坦普尔 大学健康科学中心购买惠普Sonos 1500， 它是一种最先进的计算真实的时间超声波扫描单元 多普勒能力。 至少有10名活跃的研究人员，其中3人是NIH资助的， 这取决于这些设备的可用性。他们被剥夺 因为医院规定禁止 病人护理机构的动物研究。拟议的单位将是 被安置在研究设施中，并致力于动物实验。 用户都需要高分辨率成像和血流测量 在他们的研究中。该工具将在项目中发挥关键作用 涉及1）调节心脏发育的分子机制 2）钙稳态在肥大和 下降的心肌细胞，3）研究机制，以改善 极早产儿脑干功能与脑血流变化 动物，4）高渗晶体复苏后的疗效 脊髓创伤，5）药物操作，以防止损伤 脑缺血再灌注，6）门静脉吻合， 肝移植，7）肠系膜上上级动脉血流 在新生儿坏死性血管炎，8）调查的基本 导致钠潴留和血管收缩的机制 充血性心力衰竭。惠普Sonos 1500将使非 侵入性成像和血流测量可用于这些 它将提高目前的分辨率和准确性， 可用的技术。例如，多普勒技术将取代 放射性微球血流法。 组织计划将由内部顾问监督， 该委员会由卫生科科长芭芭拉·沃尔夫森博士主持。 超声和诊断成像教授;它包括 大学资助计划管理处、 PI和其他寺庙教师。长期使用该仪器是 由内部咨询委员会的监督和 诊断成像部门主席的承诺， 医药费来支付维持费用。最后，这一文书将被保留 在当前的动物研究设施中;不需要翻新。