NEUROTRAUMA CLINICAL RESEARCH CENTER

我们建议在密歇根大学建立一个神经创伤临床研究中心。 迈阿密/杰克逊纪念医院医疗中心。 该计划包括 临床和基础科学的五个项目，以及临床流行病学 和生物统计学核心，其主要目标是建立一个全面的 患者登记;制定和实施预后指标 死亡率/发病率和结局;并提供持续支持， 未来的项目。 这些项目因其对以下方面的关注而统一起来： 创伤性CNS的潜在可治疗或可预防的病理机制 损伤 脑温在创伤后中枢神经系统调节中的作用 伤害是共同关注的一个特殊领域。 方案领域包括： 脑缺血患者脑温改变的临床评价 急性重型颅脑损伤，分析脑热疗的意义 与颅内压改变、CSF代谢物和临床 结果：（B）液压冲击性脑损伤后海马功能障碍 在大鼠中，整合电生理，神经递质， 行为测量;（c）创伤后微血管分析 完整性、血脑屏障和大脑皮层回路功能- （d）与脑温改变有关的受伤大鼠的机制 损伤引起的急性星形胶质细胞肿胀，重点是钙和 钙依赖性激酶;和（e）中度钙依赖性激酶的治疗作用。 低温治疗实验性脊髓挫伤 我们的节目 依赖于几个独特和杰出的机构资源a）a 1485-以大学为中心的主要医疗中心， 戴德县绝大多数头部损伤和脊髓损伤病例 县，其200万人口; B）一个新改组的部门 流行病学和公共卫生专家，具有数据登记方面的专门知识， 试验设计;和c）主要正在进行的研究计划，在两个大脑 代谢/缺血性脑血管疾病和脊髓损伤， 提供多学科协作专业知识的广度和深度。

We propose a Neurotrauma Clinical Research Center at the University of Miami/Jackson Memorial Hospital Medical Center. The Program consists of five projects in clinical and basic science, and a Clinical Epidemiology and Biostatistics Core, whose primary aims are to create a comprehensive patient registry; to develop and implement prognostic indicators of mortality/morbidity and outcome; and to provide ongoing support to present and future projects. The Projects are unified by their concern with potentially treatable or preventable pathomechanisms of traumatic CNS injury. The role of brain temperature in modulating post-traumatic CNS injury is a particular area of common concern. Program areas include: (a) the clinical evaluation of altered brain temperature in patients with severe acute head injury, analyzing the significance of brain hyperthermia in relation to altered intracranial pressure, CSF metabolites, and clinical outcome; (b) hippocampal dysfunction following fluid-percussion head injury in the rat, integrating electrophysiological, neurotransmitter, and behavioral measures; (c) an analysis of post-traumatic microvascular integrity, blood-brain barrier, and cortical circuit function in the head- injured rat in relation to altered brain temperature; (d) mechanisms of injury-induced acute astrocytic swelling, with a focus on calcium and calcium-dependent kinases; and (e) the therapeutic role of moderate hypothermia in experimental contusive spinal cord injury. Our program relies upon several unique and outstanding institutional resources a) a 1485-bed university-centered major medical center which receives the overwhelming majority of head-injury and spinal cord-injury cases in Dade County, with its 2 million population; b) a newly restructured Department of Epidemiology and Public Health with expertise in data registries and trial design; and c) major ongoing research programs in both cerebral metabolism/ischemic cerebrovascular disease and in spinal cord injury, providing breadth and depth of multidisciplinary collaborative expertise.