RESEARCH AND TRAINING CENTER IN HEARING AND BALANCE

这个听力和平衡研究培训中心的重点是 从毛细胞生物物理机制到迷路的研究 单侧听力损失患者的康复。这项研究 我们提出的重点是三个密切相关的领域：头发的机制 细胞损伤；单侧青光眼患者的检测和康复 前庭病变；脑干听觉中的信号处理 系统。一组三个项目集中在体外和体内 这些药理和环境作用机制的研究 关于耳毒素和减轻这些影响的方法。由四个项目组成的小组 尝试设计更好的方法来评估耳石功能，以了解更多 关于前庭-眼适应及其对设计的启示 物理疗法，以检验抗运动病的效果 药物治疗，并测试物理疗法的改善效果 对单侧病变患者前庭功能的影响。最后一组 四个项目的重点是ON和其他感官输入在 耳蜗核的信号处理。我们建议的培训计划 将整合听力和平衡方面的训练，并将提供强大的 基础科学与临床实习生和教职员工之间的互动。 该计划利用霍普金斯大学在基础和临床方面的优势 科学。在许多建立在已有的 已建立的培训计划是临床轮换的发展 对于基础科学实习生，综合研究和临床实习 对于选定的临床科学家，神经耳科博士后项目 对于耳鼻喉科医生、神经科医生、听力专家和理疗师来说， 以及一个将科学家和临床医生带到我们中心的休假计划 来自研究环境不足的机构。我们提出了一个 听力与健康平衡系列继续教育研讨会 将与公司一起解决重要临床问题的专业人员 以基础研究为基础。我们将提供进修课程。 这将使目前关于听力和平衡功能的信息 当地专业人士和非专业人士都能接触到疾病。 最后，我们建议制定一个广泛的信息传播计划。 为了接触到卫生专业人员，普通人，舆论领袖和 病人。这项计划将利用霍普金斯大学广泛的 公共事务机器。

The focus of this Research and Training Center in Hearing and Balance is the study of labyrinthine from the biophysics of hair cell mechanisms to the rehabilitation of patients with unilateral hearing loss. The research we propose is focused on three closely related areas: mechanisms of hair cell damage; testing and rehabilitation of patients with unilateral vestibular lesions; and signal processing in the brainstem auditory system. One group of three projects focuses on in vitro and in vivo studies of these mechanisms of action of pharmacological and environmental ototoxins and on ways to mitigate these effects. A group of four projects attempts to devise better ways to evaluate otolith function, to learn more about vestibula-ocular adaptation with implications for the design of physical therapies, to examine effects of anti-motion sickness medications, and to test the efficacy of physical therapy on improvement of vestibular function in patients with unilateral lesions. A final group of four projects focuses on the role of on and of other sensory inputs on signal processing in the cochlear nucleus. Our proposed training program will integrate training in hearing and balance and will provide for strong interactions between basic science and clinical trainees and faculty. This program takes advantage of the Hopkins strength in basic and clinical science. Among a number of novel features that build on an already established training program are the development of a clinical rotation for basic science trainees, an integrated research and clinical residency for selected clinician scientists, a neuro-otology postdoctoral program for otolaryngologists, neurologists, audiologists and physical therapists, and a sabbatical plan to bring scientists and clinicians to our Center from institutions with inadequate research environments. We propose a series of continuing education symposia in hearing and balance for health professionals that will address important clinical issues with a firm grounding in basic research. We will offer a continuing studies course that will make current information on hearing and balance function and disorders accessible to the local professional and lay communities. Finally, we propose to develop a broad information dissemination program to reach health professionals, the lay public, opinion leaders and patients. This program will take advantage of the extensive Hopkins Public Affairs machinery.