REGIONAL PRIMATE RESEARCH CENTER

这是一项支持杜兰区域行动的请求 灵长类动物研究中心未来五年的计划。研究将是 主要在感染性区域利用非人类灵长类完成的 疾病。本申请中描述的研究项目包括研究 To：提高我们对艾滋病所涉及的疾病过程的理解， 阐明免疫缺陷病毒毒力的分子方面 和其他逆转录病毒，检查艾滋病的母婴传播， 明确猴免疫缺陷病毒与其他病毒的相互作用 病原体，评估针对SIV和其他病毒的抗病毒物质， 明确肾盂肾炎的病理生理机制，确定年龄的影响 和激素对尿路感染的影响，开发疫苗方法来 尿路感染，制定合理的免疫预防方法 针对莱姆病，定义丝虫感染的免疫病理学， 分离丝虫保护性抗原，分析与丝虫相关的蛋白质 疟疾催眠素，评估麻风疫苗，检查病原学 非人灵长类的关节炎，评估灵长类的麻疹疫苗接种， 识别冠状病毒在多发性硬化症中的可能作用，改善 我们对尿路感染的理解，考察了 行为和免疫反应，定义免疫球蛋白的亚类 并检查主要组织相容性复合体的基因。 非传染性疾病研究包括球状细胞项目 脑白质营养不良，灵长类圈养环境的丰富， 遥测测量膀胱生理参数及生殖功能 研究如卵母细胞培养、体外受精、超数排卵、 以及配子的超低温保存。除了研究项目之外 在核心员工中，将维持繁殖群体，其中一些是 建议扩建。灵长类中心将提供地区性和 为研究人员提供的国家资源，他们的研究计划我们可以 容得下。

This is a request for support of the operation of the Tulane Regional Primate Research Center for the next five year period. Research will be done utilizing nonhuman primates primarily in the area of infectious diseases. Research projects described in this application include studies to: improve our understanding of the disease processes involved in AIDS, elucidate the molecular aspects of virulence with immunodeficiency viruses and other retroviruses, examine maternal-fetal transmission of AIDS, define the interaction of simian immunodeficiency virus and other pathogens, evaluate antiviral substances against SIV and other viruses, define the pathophysiology of pyelonephritis, determine the effect of age and hormones on urinary tract infections, develop vaccine approaches to urinary tract infections, develop rational approaches to immunoprophylaxis against Lyme disease, define the immunopathology of filarial infections, isolate protective antigens in filariae, analyze proteins associated with the malaria hypnozoite, evaluate leprosy vaccines, examine the etiology of arthritis in nonhuman primates, evaluate measles vaccination in primates, discern the possible role of coronaviruses in multiple sclerosis, improve our understanding of urinary tract infections, examine the interaction of behavior and the immune response, define the subclasses of immunoglobulins in primates and examine genes of the major histocompatibility complex. Non-infectious disease research includes projects on globoid cell leukodystrophy, environmental enrichment of primate enclosures, the measure of bladder physiology parameters by telemetry, and reproductive studies such as oocyte culture, in vitro fertilization, superovulation, and the cryopreservation of gametes. In addition to the research programs of the core staff, breeding colonies will be maintained and some are proposed for expansion. The primate center will provide a regional and national resource for investigators whose research programs we can accommodate.