ForceBiology

机械信号在细胞的迁移、增殖、侵袭和收缩等功能中起着至关重要的作用。细胞力可以用来发现和评估新药的效果，但主要由于缺乏HTS和定量分析，在很大程度上还没有被探索。尽管人们知道它们在疾病中的重要性，但药物开发商获得产生力量的分析的机会有限，特别是在高通量筛查的背景下。目前，市场上很少有体外平台可用于测量成本和复杂性较低的平台上的迁移率和收缩能力。因此，迫切需要开发和探索细胞力量，以高通量的方式调查、筛选和发现新的药物化合物。研究表明，机械信号和收缩能力可以决定人类细胞的命运。在心血管疾病(CVD)中，机械提示导致细胞微环境僵硬，导致高血压和高脂血症等威胁生命的疾病。根据世卫组织的数据，每5例心血管疾病死亡中有4例可归因于心脏病发作和中风。血管平滑肌细胞(VSMCs)是血管壁的机械活性成分，具有收缩和扩张的能力。为了评估肌肉组织的生存能力，测量组织的收缩性能以及控制其结构是必不可少的。准确的收缩性能数据可以帮助开发更有效和更安全的药物。收缩力的产生和传递过程在决定机械效率的过程中起着重要作用。今天，市场上还没有工具来量化VSMC的收缩力量，这是一个适用于制药业的可靠、高内容的平台。ForceBiology解决了这一市场需求。

Mechanical cues play crucial role in cell function such as migration, proliferation, invasion and contraction. Cellular forces can be used for discovering and assessing the effects of new drugs but has been left largely unexplored, mainly due to lack of HTS and quantitative assays. Despite knowledge of their significance in disease, drug developers have had limited access to force-generating assays, especially in the context of high-throughput screening. Presently there are few in vitro platforms available on the market for measuring migration and contractility on a platform with reduced cost and complexity. Therefore, there is pressing need to develop and explore cellular forces to investigate, screen and discover new drug compounds in high throughput manner. Research has shown that mechanical cues and contractility can dictate the fate of a human cell. In cardiovascular disease (CVD), mechanical cues give rises to stiffening of the cellular microenvironment causing life threatening conditions such as hypertension, and hyperlipidemia. According to WHO, 4 out of 5 CVD deaths, can be attributable to heart attacks and strokes. Vascular smooth muscle cells (VSMCs) comprise the mechanically active component of the blood vessel wall endowing it with the ability to constrict and dilate. To evaluate the viability of a muscle tissue, it is essential to measure the tissue's contractile performance as well as to control its structure. Accurate contractility data can aid in development of more effective and safer drugs. the processes of contractile force generation and transmission play an important function role in defining the mechanical efficiency of VSMCs. Today there are no tools on the market to quantify the contractile forces in VSMCs in a reliable, high-content platform suitable for the pharma industry. ForceBiology addresses this market need.