Counteracting age-associated neurodegenerative diseases using chaperone-based amyloid disaggregases

使用基于伴侣的淀粉样蛋白解聚来对抗与年龄相关的神经退行性疾病

• 批准号: nhmrc : 1197021
• 金额: $ 64.52万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/counteracting-age-associated-amyloid-disaggregases/1779234
• 关键词: Counteracting; age; associated; neurodegenerative; diseases

In neurodegenerative diseases such as Alzheimer’s disease, proteins form clumps through changes in structure due to mutations or proteotoxic chemical insults. The formation of these toxic clumps causes brain cells to die prematurely triggering symptoms such as dementia. I have identified a molecular machine in human cells that efficiently clears these clumps. We are now developing strategies to activate this machine to repair damaged brain cells to slow/reserve neurodegenerative diseases.

在阿尔茨海默病等神经退行性疾病中，蛋白质通过突变或蛋白质毒性化学侮辱引起的结构变化形成团块。这些有毒团块的形成会导致脑细胞过早死亡，从而引发痴呆症等症状。我已经在人类细胞中发现了一台分子机器，它可以有效地清除这些团块。我们现在正在开发策略来激活这台机器来修复受损的脑细胞，以减缓/保留神经退行性疾病。