EFFECTS OF AMPT ON MELATONIN SECRETION AND 6-HYDROXYMELATONIN SULFATE EXCRETION

AMPT 对褪黑激素分泌和 6-羟基褪黑激素硫酸盐排泄的影响

• 批准号: 3764865
• 负责人: S LIN
• 金额: --
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3764865
• 关键词: excretion; hormone biosynthesis; human subject; melatonin; neurotransmitter metabolism; norepinephrine; pineal body; secretion; sign /symptom

To determine whether alpha-methyl-para-Tyrosine decreases pineal melatonin secretions and 6-hydroxymelatonin sulfate excretion. The change in AMPT induced melatonin secretion will be correlated to clinical symptoms and indirectly to assess the degree of reduced CNS norepinephrine activity due to AMPT. This ultimately may be used as a screening test for depressed patients to assist in choosing the appropriate medication.

为了确定α-甲基-对-酪氨酸是否降低松果体 褪黑激素分泌和6-羟基硫酸褪黑激素排泄。 的 AMPT诱导的褪黑激素分泌的变化将与 临床症状，并间接评估降低CNS的程度 去甲肾上腺素活性。 这最终可以用作 一项针对抑郁症患者的筛查测试， 适当的药物。