COMPUTER SYSTEMS AND APPLICATIONS FOR NUCLEAR MEDICINE

DSB开发基于计算机的数学分析、模式 用于支持诊断活动的识别和图像处理 临床中心核医学部与协作组 研究所。许多应用程序针对的是 与结构有关的功能，例如从 放射性核素脑室造影术或PET扫描(功能数据)与 MRI或CT扫描(解剖学数据)。主要应用程序已在 心脏图像数据的分析、配准和分割。一个 已开发出用于三维配准的自动化系统 重复研究的受试者的心脏PET发射数据 使用基准点或等高线。系统还被开发用于 创建体数据的投影序列、对齐 对层析数据的投影和二维数据的应用 平移和旋转的体积数据的感兴趣区域。其他 问题涉及标记的MRI，将体积数据投影到两个- 以有意义和有用的方式显示尺寸CRT屏幕 研究人员，以及如何最好地可视化体积PET的问题 叠加在具有可变透明度的MRI或CT卷上。 本项目使用的计算机平台包括VAX、Apple MacIntosh、 与IBM兼容的PC和Unix工作站。 DSB，与国家核医学部合作 在过去的6年里，临床中心设计并指定了 通用图像处理系统幻影。编程是 由LAS和核医学监督的承包商执行 部门。已完成的基本系统已移植到其他几个 NIH计算机系统，包括VAX工作站和Macintosh系统。 北美和欧洲的许多学术和商业机构 已经要求并收到了该系统的副本。工作已经开始 基于Unix工作站的下一代系统。这个系统将会 将幻影的功能与先进的3D可视化相结合， 分析和注册功能。

DSB develops systems for computer-based mathematical analysis, pattern recognition and image processing in support of diagnostic activities in the Nuclear Medicine Department of the Clinical Center and collaborating Institutes. Many applications are directed toward the correlation of function with structure, such as estimation of ventricular function from radionuclide ventriculography or PET scan (functional data) compared to MRI or CT scans (anatomical data). The primary application has been in the analysis, registration and segmentation of cardiac image data. An automated system has been developed for three-dimensional registration of cardiac PET emission data for a subject over repeated studies without use of fiducial points or contours. Systems have also been developed for the creation of sequences of projections of volumetric data, alignment of projection to tomographic data and for application of two-dimensional regions-of-interest to translated and rotated volumetric data. Other problems involve tagged MRI, projection of volumetric data to a two- dimensional CRT screen in ways that are meaningful and useful to researchers, and the problem of how best to visualize volumetric PET superimposed on an MRI or CT volume with variable levels of transparency. Computer platforms used in this project include VAX, Apple MacIntosh, IBM-compatible PCs, and UNIX workstations. DSB, in collaboration with the Nuclear Medicine Department of the Clinical Center has, over the past 6 years, designed and specified a general-purpose image processing system, MIRAGe. Programming was performed by contractors supervised by LAS and the Nuclear Medicine Department. The completed basic system has been ported to other several NIH computer systems including VAX workstations and Macintosh systems. Many academic and commercial institutions across North America and Europe have requested and received copies of the system. Work has begun on the next-generation system based on a UNIX workstation. This system will incorporate the functionally of MIRAGe with advanced 3D visualization, analysis and registration capabilities.