STUDIES OF ORGAN TRANSPLANTATION IN ANIMALS AND MAN

动物和人类器官移植的研究

• 批准号: 3095136
• 负责人: JOHN S NAJARIAN
• 金额: $ 101.2万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3095136
• 关键词: histocompatibility; transplantation

This is an application for competitive renewal of a program project grant which has been active for 24 years. It involves many investigators and many different projects all relating to the improvement of the results of organ transplantation. It is a complex grant but can be easily understood. The grant has been divided into two major sections: 1. CLINICAL PROJECTS OF HUMAN ORGAN TRANSPLANTATION and 2. EXPERIMENTAL PROJECTS UTILIZING ANIMALS OR IN VITRO TECHNIQUES This organization persists in this application for competitive renewal. The basic overall OBJECTIVES have been to: (A) Analyze and isolate the clinical problems involved in organ transplantation and precisely document clinical laboratory correlations. (B) Organize clinical trials based on available data to solve clinical problems. (C) Generate experimental approaches to help solve clinical problems. Within these objectives, all projects are organized into three essential AIMS: AIM 1: TO PREVENT ORGAN DESTRUCTION: This includes not only immunological manipulations designed to prevent rejection but also those designed to prolong patient survival and to modify or control drug toxicity and recurrent disease. AIM 2: TO COUNTERACT INFECTION: The focus here is on cytomegalovirus. AIM 3: TO MAXIMIZE REHABILITATION: The focus here is on the psychosocial effects of clinical transplantation.

这是一份计划/项目补助金竞争性续期申请 已经活跃了24年 它涉及许多调查人员， 许多不同的项目都与改善的结果， 器官移植 这是一个复杂的赠款，但可以很容易地理解。 赠款分为两大部分： 1.人体器官移植的临床计划 2.利用动物或体外技术的实验项目 该组织坚持申请竞争性续约。 基本的总体行动是： (A)分析和隔离涉及器官的临床问题 移植和精确记录临床实验室相关性。 (B)根据现有数据组织临床试验，以解决临床 问题 (C)产生实验方法来帮助解决临床问题。 在这些目标范围内，所有项目都分为三个基本部分， 目标： 目的1：预防器官退化：这不仅包括免疫学上的 旨在防止排斥反应的操作， 延长患者生存期并改变或控制药物毒性， 复发性疾病 目的2：对抗感染：这里的重点是巨细胞病毒。 目标3：最大限度地康复：这里的重点是心理社会 临床移植效果。