STUDY OF SPLENIC FUNCTION IN SICKLE-HEMOGLOBIN C DISEASE

镰状血红蛋白C病的脾功能研究

• 批准号: 3785180
• 负责人: PETER A LANE
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785180
• 关键词: altitude; hemoglobin C; human subject; sickle cell anemia; spleen disorder

The overall objective of this study is to further define spelenic function in patient with sickle cell disease, and we will test the following hypotheses: (1) that determination of the red cell pit count overestimates both the incidence and magnitude of splenic dysfunction in persons with SC disease, and (2) that the incidence of splenic dysfunction in SC disease is higher in persons who reside at moderately high altitude than those who reside at sea level.

本研究的总体目标是进一步定义Spelenic 镰状细胞病患者的功能，我们将测试 以下假设：（1）红细胞小窝计数测定 高估了脾功能障碍的发生率和程度， 人与SC疾病，和（2），发病率脾 SC疾病中的功能障碍在中度 比那些居住在海平面的人高。