SAFETY AND EFFICACY OF DMSA FOR LEAD POISONING

DMSA 治疗铅中毒的安全性和功效

• 批准号: 3784597
• 负责人: JULIAN J CHISOLM
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3784597
• 关键词: chelating agents; child (0-11); copper; diuresis; drug administration rate /duration; drug adverse effect; drug screening /evaluation; human subject; human therapy evaluation; lead poisoning; urinalysis; zinc

DMSA (2,3-dimercaptosuccinic acid) is used to treat children with moderately severe lead poisoning. DMSA is administered for 24 days. There were no serious side effects. A brisk diuresis of lead resulted. No significant increase in the output of Zn and Cu in urine was found. Experimental evidence indicates that this is a very promising new drug for lead poisoning.

DMSA（2，3-二巯基琥珀酸）用于治疗儿童 中度铅中毒 DMSA给药24天。 没有严重的副作用。 结果导致了铅的快速利尿。 尿中锌和铜的排出量没有明显增加。 实验证据表明这是一种很有前途的新药 因为铅中毒