GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 3090324
• 负责人: JOHN C RIBBLE
• 金额: $ 82.96万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3090324
• 关键词: clinical trials; human subject

The Clinical Research Center at The University of Texas Health Science Center and Hermann Hospital provides a unique environment for clinical investigation. The faculty of the University of Texas Medical School has rapidly appreciated the advantage and importance of having this multidisciplinary facility which provides meticulous control of experimental conditions, accurate monitoring of biologic phenomena, and proper collection and handling of valuable specimens. Major research areas will include: 1. Analysis of human macrophage function in response to fibrogenic particulates. 2. Effects of HIV on growth and development of hemophiliac children. 3. Localization and characterizations of the genes responsible for tuberous sclerosis. 4. Infectivity of Cryptosporidium parvum for adult humans. 5. Validation of a more convenient and simple method to diagnose distal renal tubular acidosis. 6. Analysis of whether abnormal collagen synthesis is responsible for familial aortic aneurysms. 7. Investigation of the mucosal and cell mediated immune response, viral shedding, and the pathophysiology of diarrhea in experimental Norwalk Virus gastroenteritis. 8. Characterization of myopathy in patients with HIV infection. 9. Use of positron emission tomography metabolic imaging as an early index of the effectiveness of multi-modal cancer therapy. 10. Measurement of galactose disposal and oxidation rates in newborn infants. The investigators are from clinical and basic science departments encompassing a diversified expertise in scientific disciplines. Results from these clinical investigations will have impacts on the diagnosis and treatment of clinical disorders.

德克萨斯大学健康科学临床研究中心 中心和赫尔曼医院为临床提供独特的环境 调查。 德克萨斯大学医学院的教职员工迅速 我意识到拥有多学科的优势和重要性 提供对实验条件进行细致控制的设施， 准确监测生物现象，并适当收集和 处理有价值的标本。 主要研究领域包括： 1.人巨噬细胞对纤维化反应的功能分析 微粒。 2.HIV对血友病儿童生长发育的影响 3.致病基因的定位和特征 结节性硬化症。 4.微小隐孢子虫对成人的感染性。 5.验证一种更方便和简单的方法来诊断远端 肾小管性酸中毒。 6.分析胶原蛋白合成异常是否导致 家族性主动脉瘤。 7.研究粘膜和细胞介导的免疫反应，病毒 与实验性诺瓦克腹泻的病理生理学 病毒性胃肠炎。 8.HIV感染患者的肌病特征。 9.使用正电子发射断层扫描作为早期代谢成像 多模式癌症治疗效果指标。 10.新生儿半乳糖处置和氧化率的测定 婴儿。 研究人员来自临床和基础科学系。 在科学学科方面拥有多样化的专业知识。结果 这些临床研究将对诊断和 临床疾病的治疗。