Deciphering IFN type III, TGFβ, IL-10 and adenosine pathways in natural killer cells: enhancing the innate anti-metastatic response against breast cancer progression

该项目将确定是否有一个或多个因素产生的肿瘤（如。细胞激素和代谢物）抑制NK细胞控制乳腺癌扩散。我们将使用遗传学来特异性地删除NK细胞对这些因子的反应。这是一种全新的方法，这些信息将允许在手术和局部放疗和/或化疗后更合理地设计癌症治疗。

This project will determine whether one or more factors produced in tumours (eg. cell hormones and metabolites) inhibits NK cells from controlling breast cancer spread using the best available mouse tumour models. We will use genetics to specifically delete response to these factors by NK cells. It is a completely novel approach and this information will allow for the more rational design of cancer treatments following surgery and local radiotherapy and/or chemotherapy.