HARVARD CENTER FOR THE STUDY OF KIDNEY DISEASE

这项提案是一项让调查人员参与的合作努力 哈佛医学院基础和临床系(HMS) 以及它的四个主要教学和研究分支机构(Brigham和 妇女医院(BWH)、贝丝以色列医院(BIH)、 马萨诸塞州总医院(MGH)和乔斯林糖尿病 中心(JDC)，寻求支持建立一个机构间 多学科肾脏中心致力于全面 对糖尿病肾病的认识。重头戏 这一倡议有三个方面：1)吸引新的科学 深入研究基础分子、细胞的专业知识 和糖尿病肾损害的生理机制；2) 通过以下方式发挥组成机构方案的优势 建立有意义和不受限制的机构间， 跨学科协作研究倡议；以及3) 将这些基础研究活动扩展到及时和创新 发病机制的临床和流行病学研究， 本病常见肾病的治疗与预防 代谢紊乱。几个具体的基础和临床研究 糖尿病肾病的研究已经得到资助，并已在 进展；参与这些研究的调查人员同意 分享他们的设施、方法、经验和意愿 全面参与拟建肾脏中心的活动， 包括其计划的教学和研究会议，年度 研讨会和广泛的实验室和临床培训计划。 我们相信，这个拟议的中心将促进 加速获取一般领域的知识 糖尿病和其他肾脏疾病，从而导致 改善对病人的护理。

This proposal, a collaborative effort involving investigators in the basic and clinical departments at Harvard Medical School (HMS) and four of its major teaching and research affilates (Brigham and Women's Hospital (BWH), Beth Israel Hospital (BIH), Massachusetts General Hospital (MGH), and Joslin Diabetes Center (JDC), seeks support to establish an inter-institutional mulitdisciplinary Kidney Center devoted to a comprehensive understanding of nephropathy in diabetes mellitus. The emphases in this initiative are threefold; 1) to attract new scientific expertise to the intensive study of the basic molecular, cellular and physiological mechanisms of kidney injury in diabetes; 2) to exploit the strengths of the component institutional programs by establishing meaningful and unrestricted inter-institutional, interdisciplinary collaborative research initiatives; and 3) to extend these basic research initiatives to timely and innovative clinical and epidemiological studies of the pathogenesis, treatment and prevention of the nephropathy of this common metabolic disorder. Several specific basic and clinical research studies of diabetic nephropathy are already funded and in progress; the investigators involved in these studies have agreed to share their facilities, approaches and experience and will participate fully in the activities of the proposed Kidney Center, including its planned teaching and research conferences, annual symposia and extensive laboratory and clinical training programs. It is our belief that this proposed Center will foster an acceleration in the acquisition of knowledge in the general area of diabetic and other renal diseases and thereby contribute to improved care of patients.