POLYDRUG ABUSE IN WOMEN: NIDA CLINICAL RESEARCH CENTER

女性滥用多种药物：NIDA 临床研究中心

• 批准号: 3105352
• 负责人: JACK H MENDELSON
• 金额: $ 45.83万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105352
• 关键词: drug abuse; drug abuse chemotherapy; female

Drug abuse and drug dependence is the second most common mental health disorder among young women in American today. Recent survey data also indicate that abuse of marihuana, cocaine, tobacco and alcohol by women is increasing. Yet the PHS Task Force on Women's Health Issues (1985) noted that there has been relatively little research on the health consequences of substance use and recommended "studies of the significant factors related to the onset, continuation and cessation of smoking, drinking and drug taking by women". The proposed clinical research center program focuses on the biological and behavioral antecedents, correlates and consequences of substance abuse by women. The safety and efficacy of new pharmacological treatments for cocaine, opiate and polydrug abuse will be evaluated in controlled inpatient and outpatient drug treatment programs. Parallel studies to determine if new pharmacotherapies effectively suppress cocaine self- administration in a female monkey drug self-administration model are proposed. Established operant behavioral procedures will be used to evaluate the dose range of pharmacotherapeutic efficacy and safety. Controlled clinical research ward studies are proposed to examine polydrug use patterns involving marihuana, alcohol and tobacco. Covariance between premenstrual dysphoria and drug use patterns will be examined. Neurobehavioral correlates of the development of tolerance to marihuana during chronic marihuana smoking will also be studied. Neurophysiologic and behavioral correlates of interactions between cocaine, marihuana and alcohol will be examined. Family history of substance abuse has been shown to be a significant factor in risk for polydrug abuse problems. The possible contribution of this antecedent risk factor to marihuana abuse will be evaluated by comparing sensitivity to the physiologic and behavioral effects of marihuana in women with and without a positive family history of alcohol abuse. Implementation of more effective drug abuse treatment programs and improved strategies for drug abuse prevention requires intensive analysis of biologic, behavioral and social concomitants of gender-related and gender specific factors in substance abuse.

药物滥用和药物依赖是第二常见的 当今美国年轻女性中的精神健康障碍。 最近的调查数据还表明，滥用大麻， 女性吸食可卡因、吸烟和饮酒的人数正在增加。然而， PHS妇女健康问题特别工作组(1985年)指出， 对人体健康影响的研究相对较少。 物质使用和推荐的“显著因素研究” 与吸烟的开始、持续和停止有关， 妇女饮酒和吸毒“。 拟议的临床研究中心计划侧重于 生物和行为的前因、关联和后果 女性滥用药物的情况。新药的安全性和有效性 可卡因、阿片类药物和多药的药理治疗 滥用将在受控制的住院和门诊药物中进行评估 治疗方案。平行研究以确定新的 药物治疗有效地抑制可卡因自身 雌性猕猴药物自我给药模型中的给药 都被提出了。已建立的可操作性行为程序将是 用于评价药物治疗效果的剂量范围 和安全。 建议进行对照临床研究病房研究以检查 涉及大麻、酒精和烟草的多种药物使用模式。 经前焦虑症与药物使用方式的协方差 将会被检查。神经行为与发育的相关性 在长期吸食大麻期间对大麻的耐受性将 也有待研究。精神分裂症的神经生理学和行为相关性 可卡因、大麻和酒精之间的相互作用将是 检查过了。有药物滥用家族史的人被证明 是多药滥用问题风险的一个重要因素。这个 这一先期危险因素对大麻的可能贡献 滥用将通过比较敏感度与 大麻对女性精神分裂症患者的生理和行为影响 而且没有酗酒的家族史。 实施更有效的药物滥用治疗方案 而改进的药物滥用预防战略需要 对生物、行为和社会伴随的深入分析 关于药物滥用中与性别有关的因素和性别特定因素。