BACTERIAL INTERRELATIONSHIPS IN AN ANIMAL MODEL

1)研究体内灵知生菌中的细菌相互关系 变形链球菌、乳杆菌的动物模型 干酪和粘性放线菌。 2)确定连续接种的效果。 细菌的定植和随后的龋齿的产生。 3)确定单核细胞对龋病发生的影响。 和多重接种。 4)确定宿主响应的调制效应 一种或多种对细菌的定植和生产 龋齿。 5)将在活体模型中获得的结果与 在体外实验中获得的那些(Clarkson，R01 Root 龋病的体外研究)。

1) To study bacterial interrelationships in an in vivo gnotobiotic animal model of the bacteria Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. 2) To determine the effects of sequential inoculation of the colonization of bacteria and subsequent production of caries. 3) To determine the effect on the production of caries of mono- and of multiple inoculation. 4) To determine the effects of modulation of the host response to one or more of the bacteria on the colonization and production of caries. 5) To compare the results obtained in the in vivo model with those obtained in the in vitro experiment (Clarkson, R01 Root caries study in vitro).