IMMUNOBIOLOGY OF GUINEA PIG INCLUSION CONJUNCTIVITIS

反复或反复发生角膜混浊和血管形成 慢性衣原体眼部感染，可能导致失明。 导致角膜混浊的机制是已知的，但可能是 由衣原体成分过敏引起的。学习 慢性衣原体感染期间角膜受累，我们有 建立了一种用豚鼠进行局部治疗的动物模型 青霉素感染鹦鹉热杆菌GPIC株。角膜 混浊和血管化只在动物身上同时发生 用GPIC试剂感染，青霉素治疗。不透明度 GPIC试剂清除结膜溶解； 然而，角膜会遭受永久性的损害，这一点得到了证明 修复后几个月观察血管形成和瘢痕形成 不透明。这种动物模型将有助于研究其作用。 衣原体和衣原体成分在角膜发育中的作用 衣原体感染期间的损害。鹦鹉热链球菌GPIC罐 除了感染结膜外，还会感染生殖道。我们有 利用这一模型来确定是否对衣原体过敏 发生在豚鼠的输卵管和子宫中 有过阴道感染史。它们的子宫和输卵管 动物在接种沙门氏菌后出现显著炎症 鹦鹉热杆菌GPIC菌株的提取物。这种炎症需要 被进一步表征，以确定它是否具有特征 迟发性超敏反应或细胞毒性。

Corneal opacity and vascularization occurs following repeated or chronic chlamydial ocular infections and may results in blindness. The mechanisms resulting in corneal opacity are known but may be caused by hypersensitivity to chlamydial components. To study corneal involvement during chronic chlamydial infections, we have developed an animal model using guinea pigs treated topically with penicillin during infection with C. psittaci strain GPIC. Corneal opacity and vascularization occurs only in animals simultaneously infected with GPIC agent and treated with penicillin. Opacity resolves with clearance of GPIC agent from the conjunctivae; however, the cornea sustains permanent damage as evidenced by vascularization and scarring observed months after resolution of opacity. This animal model will be useful to study the role of chlamydiae and chlamydial components in the development of corneal damage during chlamydial infections. C. psittaci strain GPIC can infect the genital tract in addition to the conjunctiva. We have utilized this model to determine if hypersensitivity to chlamydiae occurs in the oviduct and uterus of guinea pigs recovered from a previous vaginal infection. The uteri and oviducts of these animals develop significant inflammation following inoculation of an extract of C. psittaci strain GPIC. This inflammation needs to be further characterized to determine whether it is characteristic of delayed hypersensitivity or of cellular toxicity.