PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION

骨髓移植中的血小板同种免疫

基本信息

项目摘要

This project will attempt to define, then prevent, delay, or reverse alloimmunization to platelet transfusions. We will evaluate patients prior to transplantation for evidence of alloimmunization based on antibody testing and radioisotope platelet survivals. Nonalloimmunized patients will be randomized to receive routinely prepared blood products or into two study arms: platelet transfusions exclusively from single unrelated donors given sequentially or platelets and red cells depleted of leukocytes. We will compare transfusion requirements, response to platelet transfusions and the development of lymphocytotoxic and platelet antibodies in these three groups. Methods will be developed for ultraviolet irradiation (UVI) of blood products and the prevention of alloimmunization with these products will be studied. In selected patients with antibodies to platelets prior to transplant, plasma exchange will be performed to remove antibodies kinetics will be evaluated by comparison to a similar group of alloimmunized patients who are not plasma exchanged. If plasma exchange is successful, specific methods of removing antibodies by ex vivo immunoabsorption with whole platelets will be developed.
这个项目将尝试定义,然后阻止,延迟,或

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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WILLIAM I BENSINGER其他文献

WILLIAM I BENSINGER的其他文献

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{{ truncateString('WILLIAM I BENSINGER', 18)}}的其他基金

Targeted Radiotherapy with 90Y-BC8 Monclonal Antibody, Fludarabine and TBI Follow
90Y-BC8 单克隆抗体、氟达拉滨和 TBI 靶向放射治疗
  • 批准号:
    8038924
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
AUTOLOGOUS MORROW TRANSPLANTATION
自体胚胎移植
  • 批准号:
    2092718
  • 财政年份:
    1989
  • 资助金额:
    --
  • 项目类别:
TRANSFUSION SUPPORT--CORE
输血支持--核心
  • 批准号:
    3819940
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TRANSFUSION SUPPORT--CORE
输血支持--核心
  • 批准号:
    3938018
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION
骨髓移植中的血小板同种免疫
  • 批准号:
    3805848
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TRANSFUSION SUPPORT--CORE
输血支持--核心
  • 批准号:
    3805850
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
TRANSFUSION SUPPORT--CORE
输血支持--核心
  • 批准号:
    3816014
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION
骨髓移植中的血小板同种免疫
  • 批准号:
    3811905
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION
骨髓移植中的血小板同种免疫
  • 批准号:
    3816012
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION
骨髓移植中的血小板同种免疫
  • 批准号:
    3938016
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

相似海外基金

Effect of blood donor sex and testosterone on predisposition to hemolysis in stored red blood cells
献血者性别和睾酮对储存红细胞溶血倾向的影响
  • 批准号:
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  • 财政年份:
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    2018
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用于检测寨卡病毒抗体的血清学检测,用于临床诊断和献血者咨询
  • 批准号:
    10221519
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Serologic assays for detection of Zika virus antibodies for clinical diagnosis and blood donor counseling
用于检测寨卡病毒抗体的血清学检测,用于临床诊断和献血者咨询
  • 批准号:
    10081089
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Blood Donor Competence, Autonomy and Relatedness Enhancement (Blood Donor CARE)
献血者能力、自主性和相关性增强(献血者护理)
  • 批准号:
    9204858
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
Blood Donor Competence, Autonomy and Relatedness Enhancement (Blood Donor CARE)
献血者能力、自主性和相关性增强(献血者护理)
  • 批准号:
    9012195
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
STRENGTHENING BLOOD DONOR ASSOCIATION IN MOZAMBIQUE
加强莫桑比克献血者协会
  • 批准号:
    8470294
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
Blood Donor Drives & High School Students to Educate People About Organ Donation
献血活动
  • 批准号:
    8503816
  • 财政年份:
    2012
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    --
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Blood Donor Drives & High School Students to Educate People About Organ Donation
献血活动
  • 批准号:
    8720768
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
GH12-1223 STRENGTHENING BLOOD DONOR ASSOCIATION IN MOZAMBIQUE
GH12-1223 加强莫桑比克献血者协会
  • 批准号:
    8728657
  • 财政年份:
    2012
  • 资助金额:
    --
  • 项目类别:
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