PLATELET ALLOIMMUNITY IN MARROW TRANSPLANTATION
骨髓移植中的血小板同种免疫
基本信息
- 批准号:3819938
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:antileukocyte isoantibody blood donor bone marrow transplantation cell mediated cytotoxicity cellular immunity chronic disease /disorder delayed hypersensitivity dogs fibrinogen flow cytometry histocompatibility typing human subject immunoglobulins immunosuppression leukocyte antigen typing major histocompatibility complex myelogenous leukemia neoplasm /cancer immunotherapy platelet transfusion plateletpheresis radioimmunoassay radiotracer remission /regression ultraviolet radiation
项目摘要
This project will attempt to define, then prevent, delay, or
reverse alloimmunization to platelet transfusions. We will
evaluate patients prior to transplantation for evidence of
alloimmunization based on antibody testing and radioisotope
platelet survivals. Nonalloimmunized patients will be randomized
to receive routinely prepared blood products or into two study
arms: platelet transfusions exclusively from single unrelated
donors given sequentially or platelets and red cells depleted of
leukocytes. We will compare transfusion requirements, response
to platelet transfusions and the development of lymphocytotoxic
and platelet antibodies in these three groups. Methods will be
developed for ultraviolet irradiation (UVI) of blood products and
the prevention of alloimmunization with these products will be
studied.
In selected patients with antibodies to platelets prior to
transplant, plasma exchange will be performed to remove
antibodies kinetics will be evaluated by comparison to a similar
group of alloimmunized patients who are not plasma exchanged.
If plasma exchange is successful, specific methods of removing
antibodies by ex vivo immunoabsorption with whole platelets will
be developed.
这个项目将尝试定义,然后阻止,延迟,或
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM I BENSINGER其他文献
WILLIAM I BENSINGER的其他文献
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{{ truncateString('WILLIAM I BENSINGER', 18)}}的其他基金
Targeted Radiotherapy with 90Y-BC8 Monclonal Antibody, Fludarabine and TBI Follow
90Y-BC8 单克隆抗体、氟达拉滨和 TBI 靶向放射治疗
- 批准号:
8038924 - 财政年份:2011
- 资助金额:
-- - 项目类别:
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