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THE MANIPULATION OF IMMUNE PROCESSES WITH HETEROCROSSLINKED ANTIBODIES

THE MANIPULATION OF IMMUNE PROCESSES WITH HETEROCROSSLINKED ANTIBODIES
用异源交联抗体操纵免疫过程
批准号：
3939230
负责人：
D M SEGAL
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3939230
关键词：
T lymphocyte antiantibody antibody specificity antitumor antibody blocking antibody cell aggregation cell population study clone cells crosslink cytolysis flow cytometry histocompatibility antigens human tissue immunoconjugates interleukin 2 major histocompatibility complex monoclonal antibody neoplasm /cancer immunotherapy neoplastic cell ovary neoplasms radiotracer spleen surface antigens

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英文摘要
1. Human T cells and K cells targeted with anti-T3 and anti-FcR, heterocrosslinked to anti-tumor antibodies eradicate established human ovarian cancer cells in nude mice. 2. Heterocrosslinked antibodies containing an antibody against a soluble antigen linked to an antibody against a cell surface determinant on an antigen presenting cell (APC), greatly enhance the efficiency of antigen presentation. Enhance presentation has been seen when antigen was targeted to Fc receptors, surface immunoglobulin, MHC class I and MHC class II molecules on the APC. Targeted antigen presentation is antigen specific and I-A restricted.
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