CORE - HUMAN STUDIES AND BRONCHOALVEOLAR LAVAGE

人体研究和支气管肺泡灌洗核心将提供 12个SCOR项目中9个项目的人体标本和临床数据。 它的目标是招募和评估人类疾病患者。 有兴趣的和正常的志愿者，进行支气管肺泡 对这些受试者进行灌洗(BAL)，以进行标准化分析 这些细胞的类型、蛋白质、脂质和血管紧张素转换酶 液体，为7个单独项目的研究提供BAL细胞， 并在2个项目中为研究提供人肺组织。这个 核心设施将维护和管理与以下各项相关的临床数据 这些标本与研究结果相关联。《核心》 将对大鼠BAL液进行有限的生化分析，以 实现专业知识和设备的节约。人类受试者 患有特发性肺纤维化，成人呼吸窘迫 综合征、过敏性肺炎、结节病、石棉 暴露、二氧化硅暴露和健康的正常志愿者将 学习。核心中心将由三名临床医生组成，他们具有 在人体研究方面有丰富的经验，广泛 间质性肺病和BAL，并将由一个 高技能和经验丰富的技术人员。自动化 许多灌洗液分析所需的设备可通过 这个设施。核心C是必要的，以便获得和处理 人类BAL标本的标准化和最大效率 时尚。核心设施的临床活动是必不可少的 支持佛蒙特州的基础科学实验室 肺部SCOR。

The Human Studies and Bronchoalveolar Lavage Core will provide human specimens and clinical data for 9 of the 12 SCOR projects. Its aims are to recruit and evaluate human patients with diseases of interest and normal volunteers, to perform bronchoalveolar lavage (BAL) on these subjects, to carry out standardized analyses of cell types, proteins, lipids, and angiotensin convertase in these fluids, to supply BAL cells for research in 7 individual projects, and to provide human lung tissue for study in 2 projects. The Core Facility will maintain and manage clinical data related to these specimens for correlation with research results. The Core will perform limited biochemical analyses of rat BAL fluids to achieve economy of expertise and equipment. Human subjects with idiopathic pulmonary fibrosis, adult respiratory distress syndrome, hypersensitivity pneumonitis, sarcoidosis, asbestos exposure, silica exposure, and healthy normal volunteers will be studied. The Core will be staffed by three clinicians with extensive experience in human subjects research, diffuse interstitial lung disease, and BAL, and will be supported by a highly skilled and experienced technologist. Automated equipment for many of the lavage analyses is available through this facility. Core C is necessary in order to obtain and process human BAL specimens in a standardized and maximally efficient fashion. The clinical activities of the Core Facility are essential to support the basic science laboratories of the Vermont Pulmonary SCOR.