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EXPERIMENTAL LEUKEMOGENESIS

EXPERIMENTAL LEUKEMOGENESIS
实验性白血病发生
批准号：
3093091
负责人：
ROBERT S SCHWARTZ
金额：
$79.76万
依托单位：
TUFTS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1987
资助国家：
美国
项目状态：
已结题
起止时间：
1987-01-01 至 1988-02-29
来源：
https://reporter.nih.gov/project-details/3093091
关键词：
oncogenic virus viral leukemogenesis virus genetics

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中文摘要
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英文摘要
This Program Project deals with experimental leukemogenesis. Callaborative investigations of cellular and virological mechanisms related to leukemogenesis are proposed. The expression of endogenous Type C RNA viruses by lymphocytes in various stages of differentiation will be analyzed and related to the development of leukemia. Neoplastic and normal lymphocytes will be used to identify and analyze cells that are targets of transforming viruses. Virus expression by cells in different stages of malignant transformation will be ascertained. The contribution of lymphocyte differentiation to the formation of recombinant viruses will be determined. The genetic structure of the latter agents will be determined and related to their biological effects. Transforming and non-transforming avian oncornoaviruses will be used to determine structure-function relations of src genets.
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