RADIOTELEMETRIC EVALUATION OF INTERPROXIMAL PLAQUE PH

这项拨款申请的目的是为 人近端牙菌斑pH值调频无线电遥测系统的研制 爱荷华大学。该系统将用于菌斑pH值的评估 在不同的食物消费模式期间，用于评估 抗糖酵解口腔漱口水。研究将分三个阶段进行。 第一阶段将包括体外开发和测试 FM-无线电测菌斑pH系统。最初，一款最近商业化的 可用的调频发射机将调整为与玻璃pH值一起使用 微电极。我们将采取两种方法。其中的第一个 需要一个完全封装的版本，该版本将被设计为 在人类志愿者口腔中的任何时候。第二种方法将 允许使用目前使用的留置导线遥测器具 适用于在需要调频遥测时连接调频发射机。这个 将在缓冲解决方案中评估遥测包的可靠性， 精确度和平均寿命。以下是令人满意的 性能，在第二阶段，遥测方法将用于 八名人类志愿者。志愿者将根据斑块的PH值进行选择 假设最大菌斑pH对可发酵菌斑响应的筛选方法 碳水化合物。每个志愿者将进行八个不同的测试阶段 包括8至24小时的连续斑块pH测量。 每节课的目的是评估一种特定的食物摄入量。 图案。结果将被分析并用于选择符合以下条件的食物序列 最大限度地减少产酸反应。第三阶段将有限度地进行 评价不同抗糖酵解口腔漱口液的志愿者数量 它们对长期(12小时)斑块pH反应的影响。 这种调频无线电遥测方法的发展提供了一个重要的 改进评价食物消费模式的方法 通过使用人体近端菌斑间pH值进行测量。会是 用于帮助制定新的建议和方法，以 预防龋齿的方法。

The purpose of this grant application is to obtain support for the development of a human interproximal fm-radiotelemetric plaque pH system at the University of Iowa. This system will be used for plaque pH evaluation during various food consumption patterns and for the evaluation of anti-glycolytic oral rinses. The study will be conducted in three phases. The first phase will consist of the in vitro development and testing of an fm-radiotelemetric plaque pH system. Initially, a recently commercially available fm transmitter will be adapted for use with a glass pH microelectrode. Two types of approaches will be taken. The first of these entails an entirely encapsulated version which will be designed to remain in the human volunteers oral cavity at all times. The second approach will allow use of the currently used indwelling wire-telemetric appliance adapted to connect the fm-transmitter when fm-telemetry is desired. The telemetric packages will be evaluated in buffer solutions for reliability, accuracy and average life-time expectancy. Following satisfactory performance, in Phase II the telemetric method will be applied for use in eight human volunteers. Volunteers will be selected using plaque pH screening methods to assume maximum plaque pH responses to fermentable carbohydrates. Each volunteer will carry out eight different test sessions consisting of between 8 and 24 hours of continuous plaque pH measurement. Each session will be designed to evaluate a particular food consumption pattern. Results will be analyzed and used to select food sequences that minimize acidogenic responses. Phase III will be conducted in limited numbers of volunteers to evaluate various anti-glycolytic oral rinses for their effect on long-term (12 hours) plaque pH responses. The development of this fm radiotelemetric method provides a significant improvement in the approach to evaluation of food consumption patterns through the use of human interproximal plaque pH measurement. It will be used to aid in the development of new recommendations and approaches to caries preventions.