BEHAVIORAL FUNCTIONS OF NEUROPEPTIDES

A.Galanin在小鼠体内产生了与东莨菪碱和MK-801类似的图谱 延迟与样本内存任务不匹配。甘丙素减少选择 侧脑室腹侧微量注射DNMT的准确性 大鼠海马区、大细胞基底核。甘丙素是 发现在脑室旁微量注射可刺激进食 下丘脑核和杏仁中央核。新的 甘丙肽拮抗剂C7、M40和M32可阻断甘丙素诱导的摄食 当脑室内或室旁核给药时 下丘脑，剂量等于或低于等摩尔的拮抗剂 甘丙素剂量。 B.推拉灌流被发现有相当高的恢复率 并允许用标准的放射免疫分析法检测 包括缩胆囊素和甘丙素。从原子核中分离样本 伏立本高效液相色谱法和放射免疫法分别测定大鼠脑内多巴胺和CCK 相同的采样周期，在大鼠的喂养范例中。一种CCK-B拮抗剂 核微透析液中多巴胺浓度升高 麻醉大鼠的伏隔核。50 mM钾刺激增加 腹侧海马区推拉灌流液中甘丙素的浓度 麻醉的大鼠。

A. Galanin produced a profile similar to scopolamine and MK-801 on the delayed non-matching to sample memory task. Galanin decreased choice accuracy on DNMTS when microinjected into the lateral ventricle, ventral hippocampus, and nucleus basalis magnocellularis of rats. Galanin was found to stimulate feeding when microinjected into the paraventricular nucleus of the hypothalamus and central nucleus of the amygdala. New galanin antagonists, C7, M40, and M32, blocked galanin-induced feeding when administered intraventricularly or into the paraventricular nucleus of the hypothalamus, at doses of antagonists equimolar to or lower than galanin doses. B. Push-pull perfusion was found to have considerably higher recoveries than microdialysis, and allowed detection by standard radioimmunoassay of both cholecystokinin and galanin. Split samples from the nucleus accumbens allowed measurement of dopamine by HPLC and CCK by RIA in the same sampling period, in a feeding paradigm in rats. A CCK-B antagonist increased dopamine concentrations in microdialysate from the nucleus accumbens of anesthetized rats. 50 mM potassium stimulation increased galanin concentrations in push-pull perfusate from the ventral hippocampus of anesthetized rats.