Deferiprone to Delay Dementia (The 3D study)

去铁酮可延缓痴呆（3D 研究）

• 批准号: nhmrc : GNT1123625
• 负责人: A/Pr Kathryn Ellis
• 金额: $ 185.5万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/deferiprone-delay-dementia-3d-study/1347357
• 关键词: Deferiprone; Delay; Dementia; 3D; study

There are currently no drugs available to prevent or slow deterioration in Alzheimer’s disease – which is a major incurable dementia. Our recent findings demonstrate that high brain iron levels worsen brain performance and cause people to develop Alzheimer’s disease at an earlier point in time. We propose a clinical trial of deferiprone, a drug that lowers brain iron levels, to determine if this would slow deterioration in Alzheimer’s disease once it is first detected.

目前还没有药物可以预防或减缓阿尔茨海默病的恶化，这是一种主要的无法治愈的痴呆症。我们最近的研究结果表明，高脑铁水平会使大脑功能恶化，并导致人们在更早的时候患上阿尔茨海默病。我们建议进行一项去铁素的临床试验，一种降低脑铁水平的药物，以确定一旦发现阿尔茨海默病，它是否会减缓病情的恶化。