EFFECT OF CAPTOPRIL ON HYDRO-OSMOTIC ACTION OF VASOPRESSIN

卡托普利对加压素水渗透作用的影响

• 批准号: 3847297
• 负责人: EMMY K BELL
• 金额: --
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3847297
• 关键词: blood chemistry; captopril; enalapril; human subject; kidney function; osmotic pressure; urinalysis; vasopressins

The effect of captopril on vasopressin-induced urinary concentration will be evaluated in eight or more normal individuals and then compared to that of enalapril. In the control phase, the subject will receive IV vasopressin. After the control phase, 25 mg. captopril and 1.25 mg. enalapril respectively will be given and subjects observed for effects on serum, urine sodium, etc.

卡托普利对加压素诱导的尿浓度的影响将 在八个或更多的正常人中进行评估，然后与 依那普利 在对照阶段，受试者将接受IV 加压素在对照阶段之后，25 mg.巯甲丙脯酸1.25 mg. 分别给予依那普利，观察受试者对 血清、尿钠等。