POST CORONARY ARTERY BYPASS GRAFT STUDY

冠状动脉搭桥术后研究

• 批准号: 3850375
• 负责人: J ALAN HERD
• 金额: --
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3850375
• 关键词: antihyperlipoproteinemic agent; atherosclerosis; cardiovascular disorder chemotherapy; cardiovascular disorder prevention; chemoprevention; cholesterol; combination chemotherapy; coronary bypass; dosage; heart function; human morbidity; human subject; human therapy evaluation; lovastatin; low density lipoprotein; postoperative state; quality of life; warfarin

The purposes of this project are to: 1) evaluate the effects of: a)lipid- lowering drugs (lovastatin) in an intense versus moderate lowering of LDL cholesterol levels, b) low dose of warfarin, and c) the two in combination on past CABG saphenous vein graft patency and 2) to evaluate the effects of these interventions on progression of coronary atherosclerosis in native vessels and internal mammary grafts, ventricular function, morbidity, and quality of life.

本项目的目的是：1）评估以下因素的影响：a）脂质- 降低药物（洛伐他汀）在强烈与中度降低LDL 胆固醇水平，B）低剂量华法林，以及c）两者联合 对既往CABG隐静脉移植物通畅性的影响; 2）评价 这些干预措施对冠状动脉粥样硬化的进展， 血管和内乳移植物，心室功能，发病率， 生活质量