SUBSTRATE REGULATION OF FREE FATTY ACID, LEUCINE AND GLUCOSE METABOLISM

游离脂肪酸、亮氨酸和葡萄糖代谢的底物调节

• 批准号: 3850689
• 负责人: J M MILES
• 金额: --
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3850689
• 关键词: aminoacid metabolism; drug administration routes; fatty acid metabolism; free fatty acids; glucose; glucose metabolism; glutamine; hormone regulation /control mechanism; human subject; insulin; ketone body; lactates; leucine; lipid metabolism; lipolysis

To reveal whether the decrease in fatty acid concentrations seen with infusions of lactate, ketone bodies or glutamine is due to antilipolytic effects of the substrate or mediated via an increase in production of insulin, a well known antilipolytic hormone.

为了揭示脂肪酸浓度的下降是否与 输注乳酸、酮体或谷氨酰胺是由于抗脂作用 底物的影响或通过增加产量来调节 胰岛素，一种众所周知的降脂激素。