VAGAL TONE AND ATTENTION IN 8 TO 12-YEAR-OLD MALES EXPOSED TO OPIATES IN UTERO

子宫内接触阿片类药物的 8 至 12 岁男性的迷走神经张力和注意力

• 批准号: 3853760
• 负责人: J E HICKEY
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853760
• 关键词: attention; embryo /fetus toxicology; ethanol; human subject; male; marijuana abuse; middle childhood (6-11); nicotine; opiate alkaloid; parasympathetic nervous system; psychophysiology; vagus nerve

We assessed vagal tone changes during an attention demanding CPT task in 12 boys (mean age 9 yrs, 5 mos) exposed prenatally to opiates and 12 (mean age 9 yrs, 10 mos) male controls. Mothers of opiate-exposed and control boys were primarily single and of lower income. Groups did not differ significantly on mother's education, income, or marital status. Racial composition of the groups also did not differ (opiate-exposed: 8 black, 4 white, controls 7 black, 5 white). Vagal tone was measured pre- and post-baseline and during the 3 tasks of the Gordon Diagnostic System. Vagal tone is a heart rate variability measure that quantifies parasympathetic inhibition of the heart. Results indicated that opiate-exposed boys failed to suppress vagal tone compared to control boys when distractors were added to a vigilance task (p .05). In normal children and adults, vagal tone is suppressed during tasks requiring sustained attention. These preliminary results indicate that normal physiological responses to increased attentional demand may be impaired in opiate-exposed boys in this age range. These physiological response patterns were not associated with prenatal alcohol, nicotine, or marijuana exposure in these samples. The design of this study does not distinguish among genetic, teratogenic, or child-rearing practice effects. Further research is needed to replicate and extend these findings as a possible risk factor for subsequent drug abuse in children exposed prenatally to opiates.

我们评估了在注意力要求CPT任务中迷走神经张力的变化， 12名男孩（平均年龄9岁，5个月）产前暴露于阿片类药物， (mean年龄9岁，10个月）雄性对照。 吸毒的母亲， 对照组男孩主要是单身和低收入。 团体没有 在母亲的教育程度、收入或婚姻状况上存在显著差异。 各组的种族组成也没有差异（阿片类药物暴露：8 黑色，4白色，对照7黑色，5白色）。 迷走神经张力测量前， 基线后和Gordon诊断系统的3项任务期间。 迷走神经张力是一种心率变异性指标， 心脏的副交感神经抑制。 结果表明 与对照组相比，暴露于阿片类药物的男孩未能抑制迷走神经张力 男孩当分心物被添加到警戒任务时（P 0.05）。 正常 儿童和成人，在需要执行任务时，迷走神经张力会受到抑制 持续关注。 这些初步结果表明，正常 对增加的注意力需求的生理反应可能受损 在这个年龄段接触鸦片的男孩中 这些生理反应 模式与产前酒精，尼古丁，或 这些样本中的大麻含量 本研究的设计不 区分遗传、致畸或育儿实践 方面的影响. 需要进一步的研究来复制和扩展这些 调查结果作为儿童随后滥用药物的可能风险因素 产前接触过鸦片