SCOR IN HYPERTENSION

高血压的评分

• 批准号: 3106702
• 负责人: ROBERT M GRAHAM
• 金额: $ 66.96万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106702
• 关键词: heart function; hypertension; ventricular hypertrophy

This multidisciplinary SCOR proposal continues to focus on the role of the heart in hypertension with emphasis on cellular, biochemical and functional mechanisms whereby the heart participates in pathogenesis of hypertensive cardiovascular disease. The broad objectives of the several proposed studies is to determine the biochemical or neurohumoral mechanisms that underlie the development of hypertensive hypertrophy of the heart and its ultimate fate in congestive heart failure as well as the role the heart and vessels play in the progression of hypertensive disease. This broad objective is carried out in five proposals, four of which focus exclusively on the heart: (1) studies of the mechanisms involved in activation of the myocardial renin angiotensin system and their physiologic relevance to cardiovascular function; (2) studies of calcium regulation in hypertensive hypertrophy; (3) mechanisms whereby stretch or other stimuli are translated into release of ANF from secretory granules in the heart; and (4) the role of the cardiac and peripheral baroreceptors in patients with salt sensitive hypertension and explores further the paradigm in which the heart may play a active role in the modulation of blood pressure levels. Finally, the dissociation between blood pressure control and the development of myocardial hypertrophy is also found in the persistence of peripheral vascular hypertrophy and may be responsible for the deterioration of renal function in patients with renal artery stenosis. This hypothesis was the basis for the prospective randomized study of surgical versus medical treatment of anatomic renal artery stenosis that is being proposed for continuation and completion in this SCOR renewal. From these many studies, at the most basic to the very applied clinical levels, we should substantially further our goals of understanding the pathogenesis of the deleterious effects of arterial hypertension with tangible implications for therapy.

这一多学科SCOR提案继续侧重于 高血压心脏，重点是细胞、生化和功能 心脏参与高血压发病机制的研究进展 心血管疾病 几个拟议的目标 研究的目的是确定生化或神经体液机制， 是高血压心脏肥大及其 充血性心力衰竭的最终结局以及心脏和 血管在高血压疾病的进展中发挥作用。 这一广泛 五项提案实现了这一目标，其中四项提案专门侧重于 （1）研究参与激活心脏的机制， 心肌肾素-血管紧张素系统及其与 心血管功能;（2）高血压病钙调节的研究 肥大;（3）拉伸或其他刺激被翻译的机制 心钠素从心脏分泌颗粒中的释放;（4） 盐敏感患者的心脏和外周压力感受器 高血压，并进一步探讨了心脏可能发挥作用的范例， 在调节血压水平中起积极作用。 最后 血压控制和发展之间的分离 心肌肥厚也被发现在周围的持续性 血管肥大，并可能导致肾功能恶化 肾动脉狭窄患者的肾功能。 这个假设是 手术与药物的前瞻性随机研究的基础 治疗解剖肾动脉狭窄， 在这次SCOR更新中继续和完成。 从这些研究中，从最基本的到非常实用的临床 我们应该大大进一步了解我们的目标， 动脉高血压有害作用的发病机制 对治疗有切实的意义