GENERAL CLINICAL RESEARCH CENTER

这项续签提案要求美国国立卫生研究院支持八张病床的综合医院 南卡罗来纳医科大学临床研究中心。 主要研究领域包括：矿物质代谢及其在健康中的调节 糖尿病和疾病；糖尿病中的血小板聚集；设计和评价 神经递质药物；前列腺素与肾积水的控制 正常父母和高血压父母的孩子的排泄；盐代谢； 肾上腺素能神经元作为普萘洛尔在人体内的储存和释放部位；检测 结缔组织病的特征；激肽释放酶-激肽系统 在肾功能、高血压和其他疾病方面；以及代谢方面， 普萘洛尔立体异构体在人体内的药代动力学和药效学 高血压患者。 拟议的工作将在以下环境中进行： 基础生物医学科学家与临床的跨学科合作 调查人员。分析和合成化学和生物化学是 对这个综合临床研究中心的工作至关重要。

This renewal proposal is requesting NIH support for an eight bed General Clinical Research Center at the Medical University of South Carolina. Major areas of study include: mineral metabolism and its regulation in health and diseases; platelet aggregation in diabetes mellitus; design and evaluation of neurotranshibitor drugs; prostaglandins and the control of renal water excretion; salt metabolism in children of normal and hypertensive parents; the adrenergic neuron as a storage and release site of propranolol in man; detection and characterization of connective tissue disease; the kallikrein-kinin system in renal function, hypertensive and other diseases; and the metabolism, pharmacokinetics and pharmacodynamics of propranolol stereoisomers in normal and hypertensive man. The proposed work is to be carried out in an environment which emphasizes interdisciplinary collaboration between basic biomedical scientists and clinical investigators. Analytical and synthetic chemistry and biochemistry are of central importance to the work in this General Clinical Research Center.