UPGRADE OF ANGIOGRAPHIC FACILITY

此共享仪器授权请求用于升级 医科大学心导管实验室 来自南卡罗来纳州。 现在的设备已经用了21年了， 频繁，并且越来越难以作为备件进行维修 partsless零件and less减available可用. 这一设施由四个公共卫生系统供资的 investigators. 三名调查员组成一个小组， 研究压力和容量超负荷心脏的独特方法 肥厚 血管造影设施拟升级， 请求过程中 在该设施中，压力和体积过载模型 肥大和完整的心室力学。 一旦 完整的心室功能已经在给定的模型中表征， Mann和库珀博士的实验室检测了分离的心肌细胞功能， 心肌细胞取自已经表征过的心室。 以这种方式 肌细胞功能障碍转化为全球性的机制， 正在研究心室功能障碍。 实验室研究异常传导通路和冷冻消融， 这些道路。 实验室是绝对必要的， 电生理导管的荧光透视放置和 冷冻导管;以及电影血管造影术，以测量和记录 导管定位。

This Shared Instrumentation Grant request is for the upgrade of the experimental cardiac catheterization laboratory at the Medical University of South Carolina. The current equipment is 21 years old, breaks down frequently, and is becoming more and more difficult to repair as spare partsless and less available. This facility is shared by four PHS-funded investigators. Three of the investigators, form a team which has brought a unique approach to the study of pressure and volume overload cardiac hypertrophy. The angiographic facility is proposed for upgrade in this request. In this facility the models of pressure and volume overload hypertrophy and intact ventricular mechanics are investigated. Once the intact ventricular function has been characterized in a given model, the laboratories of Drs. Mann and Cooper examine isolated myocyte function in myocytes taken from thechambers already characterized. In this way the mechanisms by which myocyte dysfunction are translated to global ventricular dysfunction are being studied. The laboratory studies aberrant conducting pathways and cryoablation of those pathways. The laboratory is absolutely essential for the fluoroscopic placement of the electrophysiologic catheters and for the cryoalation catheters; also cineangiography to measure and document catheter positioning.